Risk stratification of prostate cancer through quantitative assessment of PTEN loss (qPTEN).,Journal of the National Cancer Institute

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Risk stratification of prostate cancer through quantitative assessment of PTEN loss (qPTEN).
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2020-03-04 , DOI: 10.1093/jnci/djaa032
Tamara Jamaspishvili _{1,

2} , Palak G Patel _{1,

2} , Yi Niu _{3,

4} , Thiago Vidotto _{1,

5,

6} , Isabelle Caven _{1,

2} , Rachel Livergant _{1,

2} , Winnie Fu _{1,

2} , Atsunari Kawashima _{1,

2,

7} , Nathan How _{1,

2} , John B Okello _{1,

2} , Liana B Guedes ₈ , Veronique Ouellet ₉ , Clarissa Picanço ₆ , Madhuri Koti _{1,

5,

10} , Rodolfo B Reis ₁₁ , Fred Saad _{9,

12} , Anne-Marie Mes-Masson _{9,

13} , Tamara L Lotan _{8,

14} , Jeremy A Squire ₆ , Yingwei P Peng _{3,

15,

16} , D Robert Siemens ₁₀ , David M Berman _{1,

2,

5}

Affiliation

Division of Cancer Biology & Genetics, Queen's Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
School of Mathematical Sciences, Dalian University of Technology, Dalian, Liaoning 116024, China.
Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V7, Canada.
Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil.
Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
Institut du Cancer de Montréal and Centre de Recherche du Centre hospitalier de l, 'Université de Montréal, Montréal, Québec H2X 0A9, Canada.
Urology, Queen's University, Kingston, ON K7L 2V7, Canada.
Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil.
Department of Surgery, Université de Montréal, Montréal, Québec H2X 0A9, Canada.
Department of Medicine, Université de Montréal, Montréal, Québec H3C 3J7, Canada.
Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA.
Department of Public Health Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Mathematics and Statistics, Queen's University, Kingston, ON K7L 3N6, Canada.

Phosphatase and tensin homolog (PTEN) loss has long been associated with adverse findings in early prostate cancer. Studies to date have yet to employ quantitative methods (qPTEN) for measuring of prognostically relevant amounts of PTEN loss in postsurgical settings and demonstrate its clinical application.

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