Defining trained immunity and its role in health and disease.,Nature Reviews Immunology

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Defining trained immunity and its role in health and disease.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-03-04 , DOI: 10.1038/s41577-020-0285-6
Mihai G Netea _{1,

2,

3} , Jorge Domínguez-Andrés _{1,

2} , Luis B Barreiro _{4,

5,

6} , Triantafyllos Chavakis _{7,

8} , Maziar Divangahi _{9,

10,

11} , Elaine Fuchs ₁₂ , Leo A B Joosten _{1,

2} , Jos W M van der Meer _{1,

2} , Musa M Mhlanga _{13,

14} , Willem J M Mulder _{15,

16,

17} , Niels P Riksen _{1,

2} , Andreas Schlitzer ₁₈ , Joachim L Schultze ₃ , Christine Stabell Benn ₁₉ , Joseph C Sun _{20,

21,

22} , Ramnik J Xavier _{23,

24} , Eicke Latz _{25,

26,

27}

Affiliation

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Department of Genetics, CHU Sainte-Justine Research Centre, Montreal, QC, Canada.
Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
Genetics Section, Department of Medicine, The University of Chicago, Chicago, IL, USA.
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Meakins-Christie Laboratories, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
McGill International TB Centre, McGill University Health Centre, Montreal, QC, Canada.
Howard Hughes Medical Institute, Robin Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Division of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Gene Expression and Biophysics Unit, Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal.
Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Myeloid Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Bandim Health Project, OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
German Center for Neurodegenerative Diseases, Bonn, Germany.

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

中文翻译：

定义训练有素的免疫力及其在健康和疾病中的作用。

免疫记忆是获得性免疫系统的一个决定性特征，但先天免疫系统的激活也会导致对后续触发因素的反应增强。这个过程被称为“训练有素的免疫”，一种事实上的先天免疫记忆。过去十年的研究指出，训练有素的免疫力对宿主防御有广泛的好处，但也表明免疫介导的和慢性炎症性疾病可能会产生有害的结果。在这里，我们将“受过训练的免疫”定义为一个生物学过程，并讨论了形成受过训练的免疫诱导的先天刺激以及表观遗传和代谢重编程事件。

更新日期：2020-03-04

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