Immune metabolism regulation of the germinal center response.,Experimental & Molecular Medicine

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Immune metabolism regulation of the germinal center response.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-03-04 , DOI: 10.1038/s12276-020-0392-2
Seung-Chul Choi ₁ , Laurence Morel ₁

Affiliation

The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have provided a better understanding of how metabolic pathways regulate the development, activation and functions of immune cells. Germinal centers are transient, highly dynamic microanatomic structures that develop in lymphoid organs during a T-cell-dependent humoral immune response. Analysis of germinal centers provides an opportunity to understand how metabolic programs control the differentiation and function of highly specialized germinal center B cells and follicular helper CD4+ T cells. Targeting immunometabolism during the germinal center response may afford the possibility to improve vaccine design and to develop new therapies to alleviate autoimmunity. In this review, we discuss the major metabolic pathways that are used by germinal center B and T cells, as well as the plasma cells that they produce, all of which are influenced by the microenvironment of this unique structure of the adaptive immune system.

中文翻译：

免疫代谢调节生发中心反应。

体液免疫反应需要生发中心产生对抗病原体的高亲和力抗原特异性抗体。大量研究已经更好地了解了代谢途径如何调节免疫细胞的发育，激活和功能。生殖中心是短暂的，高度动态的微解剖结构，在依赖T细胞的体液免疫反应中在淋巴器官发育。生发中心的分析为了解代谢程序如何控制高度专业化的生发中心B细胞和滤泡性辅助CD4 + T细胞的分化和功能提供了机会。在生发中心反应期间靶向免疫代谢可能提供改善疫苗设计和开发新疗法以减轻自身免疫的可能性。在这篇评论中

更新日期：2020-04-24

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