Change from baseline is a commonly used and accepted format to show change in parameters over time in clinical studies. The statistical analysis of changes in biomarkers from baseline to week 48, comparing patients switching to the two-drug regimen dolutegravir plus rilpivirine from a standard antiretroviral regimen on day 1 (early-switch group) with those continuing their three-drug current antiretroviral regimen (CAR), and the associated p values, are a valid and appropriate analysis of data generated in the controlled portion of the SWORD studies. The method used for this statistical analysis is stated in the footnote to table S3 in the of our previous paper.

中文翻译：

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SWORD-1和SWORD-2研究中炎症生物标志物的变化-作者的回复。

从基线变化是一种常用且可接受的格式，用于显示临床研究中参数随时间的变化。对从基线到第48周生物标志物变化的统计分析，比较了在第1天从标准抗逆转录病毒方案转用双药dolutegravir加rilpivirine的患者（早期转换组）与继续采用三药物现行抗逆转录病毒方案的患者（ CAR）和相关的p值，是对SWORD研究受控部分中生成的数据的有效且适当的分析。此统计分析所用的方法在我们以前论文的表S3的脚注中说明。