Co(II)-Catalyzed Desilylative Annulation of Benzamides and Acrylamides with Alkynylsilanes: Access to 3-Methyleneisoindolin-1-one and 5-Methylene-1H-pyrrol-2(5H)-one Derivatives,Synthesis

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Co(II)-Catalyzed Desilylative Annulation of Benzamides and Acrylamides with Alkynylsilanes: Access to 3-Methyleneisoindolin-1-one and 5-Methylene-1H-pyrrol-2(5H)-one Derivatives
Synthesis ( IF 2.2 ) Pub Date : 2020-03-03 , DOI: 10.1055/s-0039-1690848
Cong Lin , Liang Shen ₁ , Jingyu Wang , Qiuxun Teng , Fei Gao , Xiuhong Liu

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The cobalt-catalyzed desilylative annulation of C(sp²)–H bonds of benzamides and acrylamides with alkynylsilanes assisted by an 8-aminoquinolyl directing group is reported. A variety of benzamides and acrylamides were compatible in this protocol to construct various 3-methyleneisoindolin-1-one and 5-methylene-1H-pyrrol-2(5H)-one derivatives with Z-configuration selectivity in moderate to high yields.

中文翻译：

苯甲酰胺和丙烯酰胺与炔基硅烷的Co（II）催化脱甲硅环化反应：获得3-亚甲基异吲哚啉-1-酮和5-亚甲基-1H-吡咯-2（5H）-衍生物

据报道，在8-氨基喹啉基导向基团的协助下，苯乙酰胺和丙烯酰胺的C（sp ²）-H键与炔硅烷进行钴催化的脱甲硅烷基化反应。多种苯甲酰胺和丙烯酰胺在该方案中相容，以中等至高产率构建具有Z-构型选择性的各种3-亚甲基异吲哚啉-1-酮和5-亚甲基-1 H-吡咯-2（5 H）-one衍生物。

更新日期：2020-03-03

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