Abstract In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells.

中文翻译：

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一种基于间三联苯五羧酸配体的新型 Zn(II) 配位聚合物，通过减少神经细胞的炎症反应和氧化应激，用于光催化亚甲蓝降解和对阿尔茨海默病的保护作用

摘要 在这项工作中，通过 4,4'-联吡啶 (4,4'-bipy) 与 Zn(NO3)2·6H2O 和间三联苯五羧酸 (H5L) 在水中反应制备了一种新型二维配位聚合物。和DMA混合溶剂，其化学式为[Zn2(HL)(4,4'-bipy)(H2O)](DMA)(1)。由于其在水中良好的骨架稳定性，配合物 1 被研究作为在紫外光下光催化降解水中亚甲蓝 (MB) 的催化剂。复合物1兼具显着的效率和良好的催化稳定性。此外，为了评估该化合物对阿尔茨海默病（AD）的治疗活性，建立AD小鼠模型并用该化合物治疗。然后，对AD小鼠脑组织进行加权，测定AD小鼠的认知功能。然后，Western blot检测海马中β淀粉样肽（Aβ）含量；ELISA检测试剂盒检测CSF中炎性细胞因子TNF-α和IL-1β；通过ROS检测试剂盒测定神经细胞内的氧化应激水平。进行CCK-8测定以检测化合物对正常人细胞的毒性。