Abstract At present, conventional drug therapy for tumor strongly stimulates tumor tissue, leading to tumor necrosis and acute inflammatory response, and tumor metastasis. How to kill tumor cells under mild conditions and prolong the survival of patients is a hot topic of tumor therapy. In this study, a multifunctional nanoplatform was designed based on mesoporous carbon nanoparticles, grafting with anti-inflammatory drug (celecoxib) and loading chemotherapy drug (doxorubicin). The constructed nanoplatform mesoporous carbon/celecoxib @doxorubicin was found to capable of, induce intravascular thrombosis, blocking nutrient supply for tumor, and over-inflammatory suppression avoiding acute tissue necrosis. Meanwhile, this study demonstrates combined chemo- and photothermal therapy and exhibits a promising potential in cancer therapy.

中文翻译：

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多功能介孔碳纳米平台在联合化疗/光疗改善肿瘤微环境中的潜在应用

摘要 目前，肿瘤的常规药物治疗强烈刺激肿瘤组织，导致肿瘤坏死和急性炎症反应，并导致肿瘤转移。如何在温和的条件下杀死肿瘤细胞，延长患者的生存期，是肿瘤治疗的热门话题。在这项研究中，基于介孔碳纳米粒子，接枝抗炎药（塞来昔布）和负载化疗药物（阿霉素）设计了多功能纳米平台。发现构建的纳米平台介孔碳/塞来昔布@doxorubicin 能够诱导血管内血栓形成，阻断肿瘤的营养供应，以及避免急性组织坏死的过度炎症抑制。同时，这项研究证明了化学和光热联合治疗，并在癌症治疗中展现出有希望的潜力。