The use of e-cigarettes to deliver aerosolized nicotine has gained popularity in recent years. Numerous reports have cited the development of acute pulmonary disease linked to vaping nicotine as well as marijuana-based products. As cultural attitudes evolve and policies shift toward the legalization of marijuana, its use has become more prevalent. Given the increased prevalence of marijuana consumption and e-cigarette usage, better insight into its potential to cause lung toxicity is warranted. The clinical, radiographic, and histopathologic characteristics of lung injury associated with vaping, particularly with marijuana-based products, have yet to be well described in the literature. We present eight patients, most of whom were admitted recently to our institution with acute respiratory failure following vaping. The majority of patients were young, with a median age of 31.5 years (range, 24-62 years) and with no known underlying lung disease. This case series highlights common clinical findings as well as the varied radiographic and histopathologic features of acute respiratory failure associated with vaping predominantly marijuana-based products. As more cases of vaping-associated pulmonary injury unfold, data will be available to further characterize this emerging disease entity. Improved understanding of disease pathogenesis and its clinical course will help clinicians determine optimal management and follow-up strategies for this patient population.

中文翻译：

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与电子烟相关的急性呼吸衰竭

近年来，使用电子烟输送雾化尼古丁已广受欢迎。许多报告都引用了与电子烟尼古丁和大麻产品有关的急性肺部疾病的发展。随着文化态度的演变和政策转向大麻合法化，大麻的使用变得更加普遍。鉴于大麻​​消费和电子烟使用率的增加，有必要更好地了解其导致肺毒性的可能性。与电子烟相关的肺损伤的临床、放射学和组织病理学特征，尤其是大麻产品，尚未在文献中得到很好的描述。我们介绍了 8 名患者，其中大多数是最近因吸电子烟后出现急性呼吸衰竭而入院的。大多数患者都很年轻，中位年龄为 31.5 岁（范围为 24-62 岁）并且没有已知的潜在肺部疾病。该病例系列突出了常见的临床发现以及与以大麻为主的产品相关的急性呼吸衰竭的各种放射学和组织病理学特征。随着越来越多的电子烟相关肺损伤病例的出现，数据将可用于进一步表征这种新出现的疾病实体。提高对疾病发病机制及其临床过程的了解将帮助临床医生确定针对该患者群体的最佳管理和随访策略。该病例系列突出了常见的临床发现以及与以大麻为主的产品相关的急性呼吸衰竭的各种放射学和组织病理学特征。随着越来越多的电子烟相关肺损伤病例的出现，将有数据可以进一步表征这种新出现的疾病实体。提高对疾病发病机制及其临床过程的了解将帮助临床医生确定针对该患者群体的最佳管理和随访策略。该病例系列突出了常见的临床发现以及与以大麻为主的产品相关的急性呼吸衰竭的各种放射学和组织病理学特征。随着越来越多的电子烟相关肺损伤病例的出现，将有数据可以进一步表征这种新出现的疾病实体。提高对疾病发病机制及其临床过程的了解将帮助临床医生确定针对该患者群体的最佳管理和随访策略。