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Preparation and application of subdivided tablets using 3D printing for precise hospital dispensing.
European Journal of Pharmaceutical Sciences ( IF 4.3 ) Pub Date : 2020-03-04 , DOI: 10.1016/j.ejps.2020.105293 Zijie Zheng 1 , Jieqiong Lv 1 , Wei Yang 1 , Xueying Pi 1 , Wei Lin 1 , Zhanyi Lin 2 , Wenfang Zhang 1 , Jiali Pang 1 , Yingtong Zeng 2 , Zhufen Lv 3 , Haiyan Lao 2 , Yanzhong Chen 3 , Fan Yang 3
European Journal of Pharmaceutical Sciences ( IF 4.3 ) Pub Date : 2020-03-04 , DOI: 10.1016/j.ejps.2020.105293 Zijie Zheng 1 , Jieqiong Lv 1 , Wei Yang 1 , Xueying Pi 1 , Wei Lin 1 , Zhanyi Lin 2 , Wenfang Zhang 1 , Jiali Pang 1 , Yingtong Zeng 2 , Zhufen Lv 3 , Haiyan Lao 2 , Yanzhong Chen 3 , Fan Yang 3
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This study aimed to use three-dimensional printing technology to provide patients with accurate, safe and convenient subdivided drugs and bring the transformation of subdivided drugs' fabrication in the hospital. The formulation, preparation process, model and printing parameters, relationship between dose and preset model for printing of spironolactone of 2 mg, 4 mg and hydrochlorothiazide of 5 mg subdivided tablets prepared by three-dimensional printers were investigated in the study. The three-dimensional printed material consists of commercial tablets powders and other excipients, including lactose, corn starch, microcrystalline cellulose, and so on. Mass variation, drug content and drug content uniformity of subdivided tablets obtained by three-dimensional printing were compared with the pharmacists splitting subdivided tablets. Besides, the results from fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray powder diffraction confirmed that the preparation process of spironolactone of 2 mg, 4 mg and hydrochlorothiazide of 5 mg did not change the crystal structure of the active pharmaceutical ingredient. Furthermore, mass variation, drug content range and drug content uniformity of spironolactone of 2 mg, 4 mg and hydrochlorothiazide of 5 mg tablets split by pharmacists failed to comply with European Pharmacopoeia and Chinese Pharmacopoeia, while those of the three-dimensional printed subdivided tablets did. After the review of the ethics committee as a new technology for hospital dispensing, three-dimensional printed spironolactone subdivided tablets of 2 mg have been used in clinical inpatients and was accepted by pharmacists, nurses and patients. Compared with tablets subdivided split by pharmacists, three-dimensional printed spironolactone tablets of 2 mg were more accurate, safer and more customized, which indicated considerable potential in using three-dimensional printing technology as a new method for hospital dispensing.
更新日期：2020-04-21
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