Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiovascular disease (CVD). As such, this phenomenon has sparked interest into the role that these single mutations may play in CVD. Atherosclerotic CVD is a complex disease and we have previously shown that atherosclerosis can be accelerated by metabolic- or autoimmune-related risk factors such as diabetes, obesity, and rheumatoid arthritis. In this review, we discuss the role of CHIP, the interplay between CHIP and metabolic diseases, as well as how metabolism of hematopoietic stem cells (HSCs) could regulate CHIP-related HSC fate.

中文翻译：

---

不确定潜能的克隆造血与代谢之间的相互作用

不确定潜能的克隆性造血 (CHIP)，定义为在一生中由单个获得性突变组成的造血细胞克隆，最近被发现是动脉粥样硬化性心血管疾病 (CVD) 的主要危险因素。因此，这种现象引起了人们对这些单一突变在 CVD 中可能发挥的作用的兴趣。动脉粥样硬化 CVD 是一种复杂的疾病，我们之前已经表明，代谢或自身免疫相关的风险因素（如糖尿病、肥胖和类风湿性关节炎）可以加速动脉粥样硬化。在这篇综述中，我们讨论了 CHIP 的作用、CHIP 与代谢疾病之间的相互作用，以及造血干细胞 (HSC) 的代谢如何调节 CHIP 相关的 HSC 命运。