Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians.,Journal of Diabetes

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Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians.
Journal of Diabetes ( IF 3.0 ) Pub Date : 2020-04-06 , DOI: 10.1111/1753-0407.13031
Nandini R Jayakumari ₁ , Raji S Rajendran ₁ , Ashok Sivasailam ₁ , Surabhi S Vimala ₁ , Saurabh Nanda ₂ , Shankarappa Manjunatha _{3,

4} , Vivek V Pillai ₂ , Jayakumar Karunakaran ₂ , Srinivas Gopala ₁

Affiliation

The cardiovascular complications associated with type 2 diabetes mellitus could be attributed to changes in myocardial mitochondrial metabolism. Though it is a known fact that permeabilized cardiac muscle fibers and isolated mitochondria are metabolically compromised in the Caucasian population, studies of Asian Indian myocardial mitochondrial function are lacking. Thus, the objective of the present study is to analyze if there is altered cardiac mitochondrial substrate utilization in diabetic Asian Indians.

中文翻译：

2型糖尿病亚洲印第安人的底物介导的心脏线粒体复合体I呼吸功能受损，脂肪酸代谢和氧化应激状态的调节未发生变化。

与2型糖尿病相关的心血管并发症可归因于心肌线粒体代谢的变化。尽管众所周知的事实是白种人人群中透化的心肌纤维和孤立的线粒体在代谢上受到损害，但仍缺乏对亚洲印度裔心肌线粒体功能的研究。因此，本研究的目的是分析糖尿病亚洲印第安人中是否存在心脏线粒体底物利用的改变。

更新日期：2020-04-06

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