Nanopatterned Polymer Surface Modulates Twist Polymorphism in a Single Amyloid Fibril.,Macromolecular Rapid Communications

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Nanopatterned Polymer Surface Modulates Twist Polymorphism in a Single Amyloid Fibril.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-03-03 , DOI: 10.1002/marc.201900619
Jingjing Liu ₁ , Mengting Tian ₁ , Lei Shen ₁

Affiliation

The periodic twist behaviors of amyloid fibrils initiated and formed on block copolymer films with nanoscale features are studied. The discovery of twist variations even in a single amyloid fibril is reported: the fibril can vary its twist extents in response to the underlying nanopatterned surfaces by keeping its neighboring crossover sections right above the periodic nanodomains and tuning the distance between neighboring crossover sections based on either the periodic nanodomain distance or the fibril contour direction. This nanopattern-induced twist polymorphism arises from the fibril's two edges, exhibiting different hydrophobic interactions with the periodic nanodomains, as demonstrated by simulation studies. This work contributes to the understanding of surface effects on twist polymorphism in amyloid fibril structures that may be important to fibril polymorphism in amyloid pathologies and bioapplications of amyloid fibrils.

中文翻译：

纳米图案化的聚合物表面可调节单个淀粉样原纤维中的扭曲多态性。

研究了在具有纳米级特征的嵌段共聚物薄膜上引发和形成的淀粉样原纤维的周期性扭曲行为。甚至在单个淀粉样蛋白原纤维中也发现了扭曲变化的发现：原纤维可以通过使其相邻的交叉部分保持在周期性纳米结构域的正上方，并根据其中一个来调整相邻交叉部分之间的距离，从而响应于下面的纳米图案表面而改变其扭曲程度。周期性纳米域距离或原纤维轮廓方向。纳米图案诱导的扭曲多态性起源于原纤维的两个边缘，与周期性纳米域表现出不同的疏水相互作用，如模拟研究所示。

更新日期：2020-04-22

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