Development of Stimulus-Responsive Degradable Film via Codeposition of Dopamine and Cystamine.,Chemistry - An Asian Journal

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Development of Stimulus-Responsive Degradable Film via Codeposition of Dopamine and Cystamine.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-03-03 , DOI: 10.1002/asia.202000216
Wonwoo Jeong ₁ , Eunseok Kim ₁ , Jaehoon Jeong ₁ , Himani Bisht ₁ , Hyeongeun Kang ₁ , Daewha Hong ₁

Affiliation

Herein, we report a degradable film that can be coated on various substrates by the codeposition of dopamine and cystamine. The thickness of the resulting film (pDC) varies depending on the initial ratio of dopamine/cystamine dissolved in a solution; the thickest film (ca. 60 nm) is obtained under optimized codeposition conditions. Selective degradation of pDC occurs in the presence of tris(2‐carboxyethyl)phosphine (TCEP), the reaction kinetics of which are highly dependent on the TCEP concentration. For further application as a drug‐delivery platform, doxorubicin can be loaded within the pDC film, which is released actively under film degradation in response to TCEP. We expect that the developed pDC film will be a useful tool for developing drug delivery cargo, antibacterial surface, and cell surface coating for various biomedical applications.

中文翻译：

通过多巴胺和胱胺的共沉积开发可刺激刺激的可降解膜。

在此，我们报道了一种可降解膜，该膜可通过多巴胺和胱胺的共沉积涂布在各种基材上。所得膜的厚度（pDC）取决于溶解在溶液中的多巴胺/胱胺的初始比例；在优化的共沉积条件下可获得最厚的膜（约60 nm）。pDC的选择性降解在三（2-羧乙基）膦（TCEP）存在下发生，其反应动力学高度依赖于TCEP浓度。为了进一步用作药物递送平台，可以将阿霉素装载在pDC膜中，该膜在TCEP的作用下由于膜降解而主动释放。我们希望开发的pDC膜将成为开发用于各种生物医学应用的药物递送货物，抗菌表面和细胞表面涂层的有用工具。

更新日期：2020-03-03

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