This study was conducted to examine the association between renal function and hip fracture. We followed up 352,624 Korean adults, who participated in health examinations during 2009–2010 until 2013. Kidney function was assessed by creatinine‐based estimated glomerular filtration rate (eGFR) and albuminuria using urine reagent strip results. The incidence of hip fracture was examined by hospital discharge records. Hazard ratios (HRs) for hip fracture were calculated using Cox proportional hazard models after adjusting for multiple confounders. During a mean follow‐up of 4.0 years, 1177 participants suffered a hip fracture. Lower eGFR and more severe albuminuria were associated with a higher risk of hip fracture. The HRs for hip fracture were 1.89 (95% confidence interval [CI] 1.47–2.43) and 3.75 (95% CI 2.30–6.11) among participants with eGFRs of 30 to 44 and 15 to 29 mL/min/1.73m² relative to those with an eGFR ≥60 mL/min/1.73m², respectively. The HRs were 1.30 (95% CI 1.02–1.65) for moderate albuminuria and 1.58 (95% CI 1.07–2.35) for severe albuminuria (p for trend = 0.002). Participants with albuminuria had a higher risk of hip fracture than those without albuminuria, even when they belonged to the same eGFR category (HR = 1.75 versus 3.30 for an eGFR of 30 to 44 mL/min/1.73m²; HR = 2.72 versus 7.84 for an eGFR of 15 to 29 mL/min/1.73m²). The effects of each 10 mL/min/1.73m² decrease in eGFR were stronger with advancing albuminuria severity (p _interaction = 0.016). In conclusion, both low eGFR and albuminuria were risk factors for incident hip fracture in Korean adults. Moreover, these factors exerted a synergistic effect on the risk of hip fracture. © 2020 American Society for Bone and Mineral Research.

中文翻译：

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慢性肾脏疾病会增加髋部骨折的风险：一项针对韩国成年人的前瞻性队列研究。

这项研究旨在检查肾功能与髋部骨折之间的关系。我们追踪了352,624名在2009–2010年至2013年期间参加健康检查的韩国成年人。使用尿液试剂条结果，通过基于肌酐的估计肾小球滤过率（eGFR）和蛋白尿评估肾功能。通过出院记录检查髋部骨折的发生率。在对多个混杂因素进行调整后，使用Cox比例风险模型计算了髋部骨折的风险比（HRs）。在平均4.0年的随访中，有1177名参与者发生了髋部骨折。较低的eGFR和较严重的蛋白尿与髋部骨折的风险较高有关。髋部骨折的心率分别为1.89（95％置信区间[CI] 1.47–2.43）和3.75（95％CI 2.30–6）。²相对于那些与EGFR≥60毫升/分钟/1.73米²分别。中度蛋白尿的HRs为1.30（95％CI 1.02–1.65），重度蛋白尿的HRs为1.58（95％CI 1.07–2.35）（趋势p = 0.002）。具有蛋白尿的参与者比没有蛋白尿的参与者发生髋部骨折的风险更高，即使他们属于相同的eGFR类别（对于eGFR为30至44 mL / min / 1.73m ^2的患者，HR = 1.75对3.30 ； HR e = 2.72对7.84 eGFR为15至29 mL / min / 1.73m ²）。eGFR每降低10 mL / min / 1.73m ^2的影响随着白蛋白尿严重程度的提高而增强（p_相互作用= 0.016）。总之，低eGFR和蛋白尿都是韩国成年人发生髋部骨折的危险因素。此外，这些因素对髋部骨折的风险具有协同作用。©2020美国骨骼和矿物质研究学会。