Regulatory T (Treg) cells potentially suppress the deleterious activities of effector T cells and maintain a state of tolerance against antigens in the airway mucosa. A decrease in the number and function of Treg cells is observed in T helper 2 (Th2)–biased allergic airway diseases. However, adoptive transfer of naturally occurring Treg (tTreg) cells or peripherally derived Treg (pTreg) cells in asthmatic mouse models did not yield satisfactory results in any previous studies. Here, we review the recent progress in the identification and plasticity of tTreg and pTreg cells in Th2–biased airway diseases and summarize the factors affecting the stability and function of Treg cells. This review may serve as foundation for understanding the molecular mechanisms underlying the stability of tTreg and pTreg cells and development of effective strategies for treating allergic airway diseases.

中文翻译：

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调节性 T 细胞在 T 辅助 2 偏向过敏性气道疾病中的稳定性

调节性 T (Treg) 细胞可能会抑制效应 T 细胞的有害活动，并在气道粘膜中保持对抗原的耐受状态。在 T 辅助 2 (Th2) 偏向的过敏性气道疾病中观察到 Treg 细胞的数量和功能下降。然而，在以前的任何研究中，在哮喘小鼠模型中过继转移天然存在的 Treg (tTreg) 细胞或外周衍生的 Treg (pTreg) 细胞都没有产生令人满意的结果。在这里，我们回顾了在 Th2 偏向性气道疾病中 tTreg 和 pTreg 细胞的识别和可塑性的最新进展，并总结了影响 Treg 细胞稳定性和功能的因素。