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T1ρ magnetic resonance fingerprinting.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/nbm.4284
Cory R Wyatt 1, 2 , Thomas M Barbara 1 , Alexander R Guimaraes 1, 2
Affiliation  

T1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1 , T2 , and T1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflammation, allowing for a potential multi-parametric approach to tissue quantification. Traditional magnetic resonance fingerprinting (MRF) has been shown to provide quick, quantitative mapping of T1 and T2 relaxation time constants. In this study, T1ρ relaxation is added to the MRF framework using spin lock preparations. An MRF sequence involving an RF-spoiled sequence with TR , flip angle, T1ρ , and T2 preparation variation is described. The sequence is then calibrated against conventional T1 , T2 , and T1ρ relaxation mapping techniques in agar phantoms and the abdomens of four healthy volunteers. Strong intraclass correlation coefficients (ICC > 0.9) were found between conventional and MRF sequences in phantoms and also in healthy volunteers (ICC > 0.8). The highest ICC correlation values were seen in T1 , followed by T1ρ and then T2 . In this study, T1ρ relaxation has been incorporated into the MRF framework by using spin lock preparations, while still fitting for T1 and T2 relaxation time constants. The acquisition of these parameters within a single breath hold in the abdomen alleviates the issues of movement between breath holds in conventional techniques.

中文翻译:

T1ρ 磁共振指纹图谱。

T1ρ 弛豫成像是一种定量成像技术,已用于评估软骨完整性、肝纤维化、肿瘤、心肌梗塞和阿尔茨海默病。T1、T2 和 T1ρ 弛豫时间常数均显示出对几种纤维化和炎症标志物的不同程度的敏感性,从而为组织量化提供了一种潜在的多参数方法。传统的磁共振指纹 (MRF) 已被证明可以提供 T1 和 T2 弛豫时间常数的快速、定量映射。在这项研究中,T1ρ 松弛被添加到使用自旋锁准备的 MRF 框架中。描述了涉及具有 TR 、翻转角、T1ρ 和 T2 准备变化的 RF 破坏序列的 MRF 序列。然后根据常规 T1、T2、琼脂模型和四名健康志愿者腹部的 T1ρ 松弛映射技术。在体模和健康志愿者 (ICC > 0.8) 的常规和 MRF 序列之间发现了强的组内相关系数 (ICC > 0.9)。最高的ICC相关值出现在T1,其次是T1ρ,然后是T2。在这项研究中,T1ρ 弛豫已通过使用自旋锁制剂纳入 MRF 框架,同时仍适合 T1 和 T2 弛豫时间常数。在腹部单次屏气内获取这些参数减轻了传统技术中屏气之间的运动问题。9) 在体模和健康志愿者的常规和 MRF 序列之间发现 (ICC > 0.8)。最高的ICC相关值出现在T1,其次是T1ρ,然后是T2。在这项研究中,T1ρ 弛豫已通过使用自旋锁制剂纳入 MRF 框架,同时仍适合 T1 和 T2 弛豫时间常数。在腹部单次屏气内获取这些参数减轻了传统技术中屏气之间的运动问题。9) 在体模和健康志愿者的常规和 MRF 序列之间发现 (ICC > 0.8)。最高的ICC相关值出现在T1,其次是T1ρ,然后是T2。在这项研究中,T1ρ 弛豫已通过使用自旋锁制剂纳入 MRF 框架,同时仍适合 T1 和 T2 弛豫时间常数。在腹部单次屏气内获取这些参数减轻了传统技术中屏气之间的运动问题。
更新日期:2020-04-22
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