Assessing the variability of 23 Na MRI in skeletal muscle tissue: Reproducibility and repeatability of tissue sodium concentration measurements in the lower leg at 3 T.,NMR in Biomedicine

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Assessing the variability of 23 Na MRI in skeletal muscle tissue: Reproducibility and repeatability of tissue sodium concentration measurements in the lower leg at 3 T.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/nbm.4279
Teresa Gerhalter _{1,

2,

3} , Lena V Gast ₁ , Benjamin Marty _{2,

3} , Michael Uder ₁ , Pierre G Carlier _{2,

3} , Armin M Nagel _{1,

4,

5}

Affiliation

The goal of this study was to evaluate the reproducibility and repeatability of tissue sodium concentration (TSC) measurements using 23 Na MRI in skeletal muscle tissue. 23 Na MRI was performed at 3 T on the right lower leg of eight healthy volunteers (aged 28 ± 4 years). The examinations were repeated at the same site after ~ 22 weeks to assess the variability over a medium-term period. Additionally, they were scanned at a second site shortly before or shortly after the first visit (within 3 weeks) to evaluate the inter-site reproducibility. Moreover, we analysed the effect of B0 correction on the variability. Coefficients of variations (CVs) from mean TSC values as well as Bland-Altman plots were used to assess intra-site repeatability and inter-site reproducibility. In phantom measurements, the B0 correction improved the quantitative accuracy. We observed differences of up to 4.9 mmol/L between the first and second visit and a difference of up to 3.7 mmol/L between the two different sites. The CV for the medium-term repeatability was 15% and the reproducibility CV was 9%. The Bland-Altman plots indicated high agreement between the visits in all muscle regions. The systematic bias of -0.68 mmol/L between site X and Y (P = 0.03) was slightly reduced to -0.64 mmol/L after B0 correction (P = 0.04). This work shows that TSC measurements in healthy skeletal muscle tissue can be performed with good repeatability and reproducibility, which is of importance for future longitudinal or multicentre studies.

中文翻译：

评估骨骼肌组织中23 Na MRI的变异性：3 T下小腿中组织钠浓度测量的可重复性和可重复性。

这项研究的目的是评估在骨骼肌组织中使用23 Na MRI进行组织钠浓度（TSC）测量的可重复性和可重复性。对8名健康志愿者（年龄28±4岁）的右小腿在3 T时进行了23 Na MRI检查。〜22周后在同一位置重复检查，以评估中期的变异性。此外，在首次访问之前或之后不久（3周内）在第二个站点进行了扫描，以评估站点间的可重复性。此外，我们分析了B0校正对变异性的影响。平均TSC值以及Bland-Altman图的变异系数（CV）用于评估站点内重复性和站点间可重复性。在幻像测量中，B0校正提高了定量精度。我们观察到第一次和第二次访问之间的差异高达4.9 mmol / L，两个不同站点之间的差异高达3.7 mmol / L。中期重复性的CV为15％，重现性的CV为9％。布兰德-奥特曼（Bland-Altman）图表明，所有肌肉区域的探访之间都具有高度一致性。B0校正后，位点X和Y之间的系统偏差-0.68 mmol / L（P = 0.03）略降至-0.64 mmol / L（P = 0.04）。这项工作表明，健康骨骼肌组织中的TSC测量可以良好的重复性和可重复性进行，这对于将来的纵向或多中心研究非常重要。中期重复性的CV为15％，重现性的CV为9％。布兰德-奥特曼（Bland-Altman）图表明，所有肌肉区域的探访之间都具有高度一致性。B0校正后，位点X和Y之间的系统偏差-0.68 mmol / L（P = 0.03）略降至-0.64 mmol / L（P = 0.04）。这项工作表明，健康骨骼肌组织中的TSC测量可以良好的重复性和可重复性进行，这对于将来的纵向或多中心研究非常重要。中期重复性的CV为15％，重现性的CV为9％。布兰德-奥特曼（Bland-Altman）图表明，所有肌肉区域的探访之间都具有高度一致性。B0校正后，位点X和Y之间的系统偏差-0.68 mmol / L（P = 0.03）略降至-0.64 mmol / L（P = 0.04）。这项工作表明，健康骨骼肌组织中的TSC测量可以良好的重复性和可重复性进行，这对于将来的纵向或多中心研究非常重要。

更新日期：2020-04-22

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