当前位置：
X-MOL 学术
›
Inorg. Chem. Front.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Hydrogen Peroxide Disproportionation with Manganese Macrocyclic Complexes of Cyclen and Pyclen.
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2020-03-03 , DOI: 10.1039/c9qi01509d David M Freire 1 , Debora Beeri 1 , Kristof Pota 1 , Hannah M Johnston 1 , Philip Palacios 2 , Brad S Pierce 3 , Benjamin D Sherman 1 , Kayla N Green 1
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2020-03-03 , DOI: 10.1039/c9qi01509d David M Freire 1 , Debora Beeri 1 , Kristof Pota 1 , Hannah M Johnston 1 , Philip Palacios 2 , Brad S Pierce 3 , Benjamin D Sherman 1 , Kayla N Green 1
Affiliation
|
The catalase family of enzymes, which include a variety with a binuclear manganese active site, mitigate the risk from reactive oxygen species by facilitating the disproportionation of hydrogen peroxide into molecular oxygen and water. In this work, hydrogen peroxide disproportionation using complexes formed between manganese and cyclen or pyclen were investigated due to the spectroscopic similarities with the native MnCAT enzyme. Potentiometric titrations were used to construct speciation diagrams that identify the manganese complex compositions at different pH values. Each complex behaves as a functional mimic of catalase enzymes. UV-visible spectroscopic investigations of the H2O2 decomposition reaction yielded information about the structure of the initial catalyst and intermediates that include monomeric and dimeric species. The results indicate that rigidity imparted by the pyridine ring of pyclen is a key factor in increased TON and TOF values measured compared to cyclen.
中文翻译：
过氧化氢歧化与Cyclen和Pyclen锰大环配合物。
过氧化氢酶家族的酶，包括具有双核锰活性位点的多种酶，通过促进过氧化氢歧化成分子氧和水而降低了活性氧的风险。在这项工作中，由于与天然MnCAT酶在光谱上的相似性，因此研究了使用锰与Cyclen或pyclen之间形成的络合物进行过氧化氢歧化。电位滴定法用于构建形态图，以鉴定不同pH值下的锰配合物组成。每个复合物的行为都类似于过氧化氢酶的功能。H 2 O 2的紫外可见光谱研究分解反应可得到有关初始催化剂和中间体（包括单体和二聚体）的结构的信息。结果表明，比起环糊精，pyclen的吡啶环赋予的刚性是导致TON和TOF值增加的关键因素。
更新日期：2020-04-24
中文翻译：
过氧化氢歧化与Cyclen和Pyclen锰大环配合物。
过氧化氢酶家族的酶，包括具有双核锰活性位点的多种酶，通过促进过氧化氢歧化成分子氧和水而降低了活性氧的风险。在这项工作中，由于与天然MnCAT酶在光谱上的相似性，因此研究了使用锰与Cyclen或pyclen之间形成的络合物进行过氧化氢歧化。电位滴定法用于构建形态图，以鉴定不同pH值下的锰配合物组成。每个复合物的行为都类似于过氧化氢酶的功能。H 2 O 2的紫外可见光谱研究分解反应可得到有关初始催化剂和中间体（包括单体和二聚体）的结构的信息。结果表明，比起环糊精，pyclen的吡啶环赋予的刚性是导致TON和TOF值增加的关键因素。
京公网安备 11010802027423号