Enhancing the targeting ability of nanoparticles via protected copolymers,Nanoscale

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Enhancing the targeting ability of nanoparticles via protected copolymers
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/03 , DOI: 10.1039/d0nr01176b
Qiang-sheng Xia _{1,

2,

3,

4,

5} , Tao Zhu _{5,

6,

7,

8,

9} , Zhong-ying Jiang _{5,

6,

7,

8,

9} , Hong-ming Ding _{1,

2,

3,

4,

5} , Yu-qiang Ma _{5,

6,

7,

8,

9}

Affiliation

It is important to maintain the balance between therapeutic efficiency and cytotoxicity when using nanomaterials for biomedical applications. Here, we propose a new method (i.e., non-covalent coating of protected copolymers onto the nanoparticle surface) to enhance the active targeting of nanoparticles to the cancer cells by combining the dissipative particle dynamics simulation and in vitro experiments. When coating the protected copolymer onto the nanoparticle surface, the uptake efficiency could be greatly altered due to the competition between the copolymer–ligand interaction and the receptor–ligand interaction—the non-covalent coating is more efficient than the covalent coating. Furthermore, the effect of the physicochemical properties of the protected copolymer on the targeting ability of nanoparticles was also investigated. This study offers useful insight into the optimal design of nanocarriers in biomedicine.

中文翻译：

通过受保护的共聚物增强纳米颗粒的靶向能力

当将纳米材料用于生物医学应用时，保持治疗效率和细胞毒性之间的平衡非常重要。这里，我们提出一个新的方法（即，受保护的共聚物到纳米颗粒表面的，非共价涂布）通过组合耗散粒子动力学模拟和以增强纳米粒子的癌细胞的主动靶向体外实验。当将受保护的共聚物涂覆在纳米颗粒表面上时，由于共聚物-配体相互作用与受体-配体相互作用之间的竞争，吸收效率可能会发生很大变化，非共价涂层比共价涂层更有效。此外，还研究了被保护的共聚物的物理化学性质对纳米颗粒靶向能力的影响。这项研究为生物医学中纳米载体的优化设计提供了有用的见识。

更新日期：2020-04-09

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