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Sensing of tubular flow and renal electrolyte transport.
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2020-03-03 , DOI: 10.1038/s41581-020-0259-8 Eric H J Verschuren 1 , Charlotte Castenmiller 1 , Dorien J M Peters 2 , Francisco J Arjona 1 , René J M Bindels 1 , Joost G J Hoenderop 1
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2020-03-03 , DOI: 10.1038/s41581-020-0259-8 Eric H J Verschuren 1 , Charlotte Castenmiller 1 , Dorien J M Peters 2 , Francisco J Arjona 1 , René J M Bindels 1 , Joost G J Hoenderop 1
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The kidney is a remarkable organ that accomplishes the challenge of removing waste from the body and simultaneously regulating electrolyte and water balance. Pro-urine flows through the nephron in a highly dynamic manner and adjustment of the reabsorption rates of water and ions to the variable tubular flow is required for electrolyte homeostasis. Renal epithelial cells sense the tubular flow by mechanosensation. Interest in this phenomenon has increased in the past decade since the acknowledgement of primary cilia as antennae that sense renal tubular flow. However, the significance of tubular flow sensing for electrolyte handling is largely unknown. Signal transduction pathways regulating flow-sensitive physiological responses involve calcium, purinergic and nitric oxide signalling, and are considered to have an important role in renal electrolyte handling. Given that mechanosensation of tubular flow is an integral role of the nephron, defective tubular flow sensing is probably involved in renal disease. Studies investigating tubular flow and electrolyte transport differ in their methodology, subsequently hampering translational validity. This Review provides the basis for understanding electrolyte disorders originating from altered tubular flow sensing as a result of pathological conditions.
中文翻译：
感觉肾小管流量和肾脏电解质运输。
肾脏是出色的器官，可以完成从体内清除废物并同时调节电解质和水平衡的挑战。尿中的尿素以高度动态的方式流经肾单位，为了使电解质稳态，需要将水和离子的重吸收速率调节为可变的管状流。肾上皮细胞通过机械感觉感测肾小管血流。自从认识到原发纤毛作为感知肾小管血流的触角以来，对这种现象的兴趣在过去的十年中有所增加。然而，管状流量感测在电解质处理中的重要性在很大程度上是未知的。调节流量敏感生理反应的信号转导途径涉及钙，嘌呤能和一氧化氮信号传导，并被认为在肾电解质处理中具有重要作用。鉴于肾小管的机械作用是肾单位不可或缺的作用，肾病中可能涉及有缺陷的肾小管流量传感。研究肾小管血流和电解质运输的研究方法不同，从而阻碍了翻译的有效性。这篇综述为理解电解质紊乱提供了基础，电解质紊乱源于病理状况导致的肾小管血流改变。
更新日期：2020-03-03
中文翻译：
感觉肾小管流量和肾脏电解质运输。
肾脏是出色的器官，可以完成从体内清除废物并同时调节电解质和水平衡的挑战。尿中的尿素以高度动态的方式流经肾单位，为了使电解质稳态，需要将水和离子的重吸收速率调节为可变的管状流。肾上皮细胞通过机械感觉感测肾小管血流。自从认识到原发纤毛作为感知肾小管血流的触角以来，对这种现象的兴趣在过去的十年中有所增加。然而，管状流量感测在电解质处理中的重要性在很大程度上是未知的。调节流量敏感生理反应的信号转导途径涉及钙，嘌呤能和一氧化氮信号传导，并被认为在肾电解质处理中具有重要作用。鉴于肾小管的机械作用是肾单位不可或缺的作用，肾病中可能涉及有缺陷的肾小管流量传感。研究肾小管血流和电解质运输的研究方法不同，从而阻碍了翻译的有效性。这篇综述为理解电解质紊乱提供了基础，电解质紊乱源于病理状况导致的肾小管血流改变。
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