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Prion protein - mediator of toxicity in multiple proteinopathies.
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41582-020-0332-8
Jacob I Ayers 1, 2 , Stanley B Prusiner 1, 2, 3
Affiliation  

A new study shows that interactions of the cellular prion protein with amyloid-β, tau and α-synuclein oligomers are important in mediating the toxicity of these proteins in Alzheimer disease and Parkinson disease. The findings suggest a shared pathway that could be a therapeutic target common to multiple neurodegenerative diseases.

中文翻译:

on病毒蛋白-多种蛋白病的毒性介质。

一项新的研究表明,细胞病毒蛋白与淀粉样蛋白β,tau和α-突触核蛋白寡聚物的相互作用在介导这些蛋白在阿尔茨海默氏病和帕金森氏病的毒性中起重要作用。研究结果表明,一条共享途径可能是多种神经退行性疾病共有的治疗目标。
更新日期:2020-03-02
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