Agitation of the syringe and release of silicone oil,Eye

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Agitation of the syringe and release of silicone oil
Eye ( IF 2.8 ) Pub Date : 2020-03-03 , DOI: 10.1038/s41433-020-0800-9
Celso de Souza Dias Júnior ₁ , Alexandre Lima Cardoso ₁ , Ana Galrão de Almeida Figueiredo ₂ , Shoko Ota ₃ , Gustavo Barreto Melo _{1,

4}

Affiliation

Background/objectives To investigate whether agitation promotes the release of silicone oil by different models of syringe used for intravitreal injection. Methods This lab study analyzed eight syringe models by light microscopy for the release of silicone oil under agitation (flick), without agitation, and positive controls. Fourier-Transform Infrared Spectroscopy (FTIR) was performed to identify the molecular compounds inside the syringes. Results A total of 240 syringes were analyzed. The presence of silicone oil droplets was observed in all positive controls. When agitated by flicking, 100% of the samples of the syringes disclosed silicone oil, except the BD Plastipak syringe, which presented 40% of positivity. Without agitation, a smaller percentage of samples with silicone oil was observed. Agitation by flicking had a 265-fold greater chance of presenting oil droplets when compared with the syringes without agitation. There was a statistically significant difference between the three conditions ( P < 0.05). Analysis of the tip of the plunger rubber by FTIR indicated the presence of polysiloxane (silicone oil) in all models of syringe. Conclusions Agitation of the syringe promotes the release of silicone oil. It is recommended to improve the technique of injection and the manufacture of specific syringes for ophthalmological use.

中文翻译：

注射器的搅拌和硅油的释放

背景/目的通过用于玻璃体内注射的不同型号的注射器，研究搅拌是否会促进硅油的释放。方法本实验室研究通过光学显微镜分析了八种注射器模型在搅拌（轻弹）、无搅拌和阳性对照下的硅油释放情况。执行傅里叶变换红外光谱 (FTIR) 以识别注射器内的分子化合物。结果共分析了 240 个注射器。在所有阳性对照中均观察到硅油液滴的存在。当通过轻弹搅动时，除了 BD Plastipak 注射器外，100% 的注射器样品都含有硅油，其阳性率为 40%。在没有搅拌的情况下，观察到较小百分比的样品含有硅油。与没有搅动的注射器相比，通过轻弹搅动产生油滴的机会要高 265 倍。三种情况之间差异有统计学意义（P < 0.05）。通过 FTIR 对柱塞橡胶尖端的分析表明，所有型号的注射器中都存在聚硅氧烷（硅油）。结论注射器的搅拌促进了硅油的释放。建议改进注射技术和眼科专用注射器的制造。结论注射器的搅拌促进了硅油的释放。建议改进注射技术和眼科专用注射器的制造。结论注射器的搅拌促进了硅油的释放。建议改进注射技术和眼科专用注射器的制造。

更新日期：2020-03-03

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