The human lipidome comprises over tens of thousands of distinct lipid species in addition to total cholesterol and the other conventional lipid traits that are routinely measurable in the peripheral circulation. Of the lipid species considered to exhibit bioactive functions, sphingolipids are a class of molecules that have shown relevance to human disease risk and cardiovascular outcomes in particular. In this issue of the JCI, Poss et al. conducted targeted lipidomics in a case-control study involving over 600 individuals and found a sphingolipid profile that predicted coronary artery disease status. In the context of emerging evidence linking sphingolipid biology with cardiovascular pathophysiology, these results suggest the potential utility of serum sphingolipids as cholesterol-independent markers of risk and even future targets for optimizing cardiovascular health.

中文翻译：

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突破表面：更多了解脂质和心血管疾病。

除了总胆固醇和通常在外周循环中可测量的其他常规脂质特性外，人类脂质组还包含数万种不同的脂质种类。在被认为具有生物活性功能的脂质物种中，鞘脂是一类与人类疾病风险和心血管疾病结果相关的分子。在本期JCI中，Poss等人。在一项涉及600多个个体的病例对照研究中进行了靶向脂质组学研究，发现鞘脂谱可预测冠状动脉疾病状态。在将鞘脂生物学与心血管病理生理学联系起来的新证据的背景下，