BACKGROUND. In retinitis pigmentosa (RP), rod photoreceptors degenerate from 1 of many mutations, after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) reduces oxidative damage and increases cone function/survival in RP models. We tested the safety, tolerability, and visual function effects of oral NAC in RP patients.

中文翻译：

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口服N-乙酰半胱氨酸改善色素性视网膜炎患者I期试验的视锥细胞功能

背景。在色素性视网膜炎（RP）中，视杆光感受器从许多突变中的1个退化，之后视锥细胞受到氧化应激的损害。在RP模型中，N-乙酰半胱氨酸（NAC）减少氧化损伤并增加视锥细胞功能/存活率。我们测试了RP患者口服NAC的安全性，耐受性和视觉功能。