The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient excess can have deleterious effects on glucose and lipid homeostasis and contribute to the development of obesity and type 2 diabetes. Nutrient partitioning is a complex integrated process under the control of hormonal and neural signals. Neural control relies on the capacity of the brain to sense circulating metabolic signals and mount adaptive neuroendocrine and autonomic responses. This review aims to discuss the hypothalamic neurocircuits and molecular mechanisms controlling nutrient partitioning and their potential contribution to metabolic maladaptation and disease.

中文翻译：

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周围营养分配的神经元控制。

外围组织中养分的适当利用，存储和转化（称为养分分配）是适应营养和代谢挑战的基本过程，因此对于维持健康的能量平衡至关重要。营养过剩期间此过程的改变可能对葡萄糖和脂质体内稳态产生有害影响，并导致肥胖和2型糖尿病的发展。营养物质分配是在激素和神经信号控制下的复杂综合过程。神经控制依赖于大脑感知循环代谢信号并建立适应性神经内分泌和自主神经反应的能力。