INTRODUCTION We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). METHODS Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. RESULTS Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. CONCLUSIONS This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

中文翻译：

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青少年（10-24岁）患有脑肿瘤的临床表现：来自国际MOBI-Kids研究的结果。

简介我们使用来自14个国家/地区的国际合作性脑肿瘤（BTs）病例对照研究MOBI-Kids的数据，研究了年龄较大的儿童（10岁或10岁以上），青少年和年轻人（直至24岁）。方法从899例BT患者的临床记录中获得信息，包括体征和症状，症状发作，诊断日期，肿瘤类型和位置。结果总的来说，所有肿瘤中低度恶性肿瘤占64％，神经上皮肿瘤占76％，神经胶质瘤占62％。在神经上皮和胚胎肿瘤病例中，男性多于女性，但患有脑膜肿瘤的女性多。最常见的部位是小脑（22％）和额叶（16％）。最常见的症状是整体头痛，包括神经胶质瘤，胚胎性和“非神经上皮性”肿瘤（60％）。它是神经胶质瘤以外的神经上皮肿瘤的惊厥/发作，以及脑膜瘤的视觉症状和体征。聚类分析表明，头痛和恶心/呕吐是超过50％临界值，联合发生率67％的唯一症状组合。总体而言，从首次症状到诊断的平均时间为1.42个月（IQR 0.53-4.80）；在12％的病例中，病程超过1年，尽管没有特别的症状与异常长或短的延迟相关。结论这是迄今为止对年轻人进行的最大的BT临床流行病学研究。确定了许多体征和症状，主要是头痛和恶心/呕吐。诊断通常很快，但是诊断延迟超过1年的时间为12％，并且没有任何症状与诊断之前明显较长的时间相关。