Due to its good biodegradability and biocompatibility, polycaprolactone (PCL) has attracted widespread attention in the field of biomedical materials. Incorporation of Zinc oxide (ZnO) into PCL has been proved an effective way to improve its antibacterial properties. However, the interfacial compatibility of the organic-inorganic system needs to be improved due to the agglomeration of nanoparticles and phase separation of ZnO and PCL matrix affect its antibacterial efficiency. In this research, the ZnO surface was modified with citric acid monohydrate (CA) to improve the interfacial properties of ZnO-PCL system. The surface modification of ZnO was analyzed by DLS, TEM, TGA, and XPS. The results suggest that CA coating process can significantly reduce the agglomeration of ZnO nanoparticles and improve dispersion stability. The uniform PCL/ZnO-CA membranes with various nanofiller contents were fabricated through the solvent casting method. DSC and TGA analysis showed that the presence of ZnO-CA nanoparticles slightly decreased the crystallinity and thermal stability of the polymer. And ZnO-CA loaded improved the mechanical properties and wettability of the composite PCL membranes. Moreover, the composite PCL membranes showed good antibacterial activity against both E. coli and S. aureus while exhibiting good cytocompatibility, which indicated that the antibacterial and no cytotoxicity biomaterials had promising application in the biomedical field.

由于其良好的生物降解性和生物相容性，聚己内酯（PCL）在生物医学材料领域引起了广泛的关注。已证明将氧化锌（ZnO）掺入PCL中是改善其抗菌性能的有效方法。然而，由于纳米颗粒的团聚，需要改善有机-无机体系的界面相容性，ZnO和PCL基质的相分离会影响其抗菌效率。在这项研究中，用柠檬酸一水合物（CA）修饰ZnO表面，以改善ZnO-PCL系统的界面性能。通过DLS，TEM，TGA和XPS分析了ZnO的表面改性。结果表明，CA包覆工艺可以显着减少ZnO纳米粒子的团聚并提高分散稳定性。通过溶剂流延法制备了具有不同纳米填料含量的均匀PCL / ZnO-CA膜。DSC和TGA分析表明，ZnO-CA纳米颗粒的存在稍微降低了聚合物的结晶度和热稳定性。负载ZnO-CA改善了复合PCL膜的机械性能和润湿性。而且，复合PCL膜对两种都显示出良好的抗菌活性。大肠杆菌和金黄色葡萄球菌具有良好的细胞相容性，这表明抗菌且无细胞毒性的生物材料在生物医学领域具有广阔的应用前景。