Catalytic, intermolecular difunctionalization of alkenes represents an efficient and diverse protocol for the buildup of molecular complexity from abundant materials by forging two chemical bonds in a single operation. Despite important progress in this area, transition-metal-catalyzed three-component difunctionalization of unactivated alkenes remains underdeveloped, mainly because of the low reactivity, reduced polarization, and high tendency toward β-hydride elimination of these compounds. In this context, nickel-catalyzed, selective, intermolecular difunctionalization methods that generally proceed via two distinct reaction pathways, migratory insertion of nickel species into alkenes and radical addition to alkenes, have been developed. This short review highlights recent advances in this area.

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镍催化未活化烯烃的三组分双官能化的最新进展

烯烃的催化分子间双官能化代表了一种有效而多样的方案，可通过在一次操作中锻造两个化学键，从丰富的材料中构建分子复杂性。尽管在该领域取得了重要进展，但未活化烯烃的过渡金属催化三组分双官能化仍未得到充分开发，这主要是由于这些化合物的反应性低，极化降低和β-氢化物消除的趋势高。在这种情况下，已经开发了镍催化的，选择性的，分子间双官能化的方法，该方法通常通过两种不同的反应途径进行，即镍物质向烯烃中的迁移插入和自由基加成到烯烃中。这篇简短的评论重点介绍了该领域的最新进展。