Until recently, endocytic trafficking and its regulators were thought to function almost exclusively on membrane-bound organelles and/or vesicles containing a lipid bilayer. Recent studies have demonstrated that endocytic regulatory proteins play much wider roles in trafficking regulation and influence a variety of nonendocytic pathways, including trafficking to/from mitochondria and peroxisomes. Moreover, new studies also suggest that endocytic regulators also control trafficking to and from cellular organelles that lack membranes, such as the centrosome. Although endocytic membrane trafficking (EMT) clearly impacts pathways downstream of the centrosome, such as ciliogenesis (including transport to and from cilia), mitotic spindle formation, and cytokinesis, relatively few studies have focused on the growing role for EMT more directly on centrosome biogenesis, maintenance and control throughout cell cycle, and centrosome duplication. Indeed, a growing number of endocytic regulatory proteins have been implicated in centrosome regulation, including various Rab proteins (among them Rab11) and the leucine-rich repeat kinase 2. In this review, we will examine the relationship between centrosomes and EMT, focusing primarily on how EMT directly influences the centrosome.

中文翻译：

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内吞膜运输控制中心体功能。

直到最近，内吞运输及其调节剂被认为几乎只在膜结合的细胞器和/或含有脂质双层的囊泡上起作用。最近的研究表明，内吞调节蛋白在运输调节中发挥更广泛的作用，并影响各种非内吞途径，包括与线粒体和过氧化物酶体之间的运输。此外，新的研究还表明，内吞调节剂还控制进出缺乏膜的细胞器（如中心体）的运输。尽管内吞膜运输 (EMT) 显然会影响中心体下游的通路，例如纤毛发生（包括运输进出纤毛）、有丝分裂纺锤体形成和胞质分裂，相对较少的研究更直接地关注 EMT 在整个细胞周期中的中心体生物发生、维持和控制以及中心体复制方面的日益增长的作用。事实上，越来越多的内吞调节蛋白与中心体调节有关，包括各种 Rab 蛋白（其中包括 Rab11）和富含亮氨酸的重复激酶 2。在这篇综述中，我们将研究中心体和 EMT 之间的关系，主要关注关于 EMT 如何直接影响中心体。