Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls,Psychoneuroendocrinology

当前位置： X-MOL 学术 › Psychoneuroendocrinology › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls
Psychoneuroendocrinology ( IF 3.4 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.psyneuen.2020.104635
Gin S Malhi ₁ , Pritha Das ₁ , Tim Outhred ₁ , Carol Dobson-Stone ₂ , Erica Bell ₃ , Danielle Gessler ₄ , Richard Bryant ₅ , Zola Mannie ₆

Affiliation

The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; ARCHI, Sydney Medical School Northern, The University of Sydney, NSW, 2006, Australia.
The University of Sydney, Brain and Mind Centre, Faculty of Medicine and Health, NSW, Australia; School of Medical Sciences, University of New South Wales, NSW, Australia.
The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia.
The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; ARCHI, Sydney Medical School Northern, The University of Sydney, NSW, 2006, Australia; The University of Sydney, Brain and Mind Centre, Faculty of Medicine and Health, NSW, Australia; School of Psychology, University of Sydney, NSW, Australia.
School of Psychology, University of New South Wales, NSW, Australia.
The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; ARCHI, Sydney Medical School Northern, The University of Sydney, NSW, 2006, Australia; NSW Health, Northern Sydney Local Health District, Royal North Shore Hospital, St Leonards, NSW, Australia.

Oxytocin (OXT) is a neuropeptide involved in social behaviour and is sensitive to environmental influences to alter individual vulnerability or resilience to stress resulting in both negative and positive outcomes. The effects of the OXT receptor (OXTR) single nucleotide polymorphism (SNP) rs53576 on hippocampal and amygdala structure and functions in adults are differentially associated with susceptibility to adversity and social behaviours, but this evidence is lacking in healthy adolescents. Adolescence is a developmental period characterised by neurobiological and psychosocial changes resulting in higher susceptibility to mood disorders, particularly among girls. As the brain is highly plastic at this stage, to understand psychosocial and emotional development, clarity of the interactions between rs53576 and adversity on hippocampal and amygdala volumes and social behaviours is needed. In this study, we investigated the interactions between rs53576 and emotional trauma (ET) exposure on hippocampal and amygdala volumes of adolescent girls, and associations with parenting style, perceived social support and bullying behaviour. Based on an unbiased and corrected analytical approach, we found smaller left hippocampal volumes in higher (hET) compared to minimally (mET) exposed AA homozygotes, but no differences in G allele carriers nor in the amygdala. Within the mET AA group, larger volumes were associated with peer perceived social support, but in their hET counterparts, smaller volumes were associated with familial perceived social support. This evidence supports an important role for the hippocampus in social behaviours but extends current knowledge to suggest that hippocampal social behavioural features are contextually dependent on rs53576.

中文翻译：

OXTR rs53576 与情绪创伤对少女海马体积和感知社会支持的相互作用

催产素 (OXT) 是一种参与社会行为的神经肽，对环境影响敏感，可以改变个体对压力的脆弱性或恢复力，从而产生消极和积极的结果。OXT 受体 (OXTR) 单核苷酸多态性 (SNP) rs53576 对成人海马和杏仁核结构和功能的影响与对逆境和社会行为的易感性不同，但在健康青少年中缺乏这种证据。青春期是一个以神经生物学和社会心理变化为特征的发育时期，导致更容易患情绪障碍，尤其是在女孩中。由于大脑在这个阶段是高度可塑性的，为了了解社会心理和情绪发展，需要明确 rs53576 与逆境对海马和杏仁核体积以及社会行为之间的相互作用。在这项研究中，我们调查了青春期女孩海马和杏仁核体积上 rs53576 与情绪创伤 (ET) 暴露之间的相互作用，以及与养育方式、感知社会支持和欺凌行为的关联。基于无偏见和校正的分析方法，我们发现与最低限度 (mET) 暴露的 AA 纯合子相比，较高 (hET) 的左侧海马体积更小，但 G 等位基因携带者和杏仁核没有差异。在 mET AA 组中，较大的音量与同伴感知的社会支持相关，但在 hET 组中，较小的音量与家庭感知的社会支持相关。

更新日期：2020-05-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11