Abstract Rapid multianalysis methods of metalaxyl-M, boscalid, picoxystrobin, fluopicolide and its metabolite 2,6-dichlorobenzamide, pyraclostrobin, and mandipropamid in grapes, wine, and raisins were established. The residue determination of six fungicides in wine-making and fruit-drying processes and evaluation were studied. The six fungicides exhibited good linearity in all three matrices (r > 0.9953). The average recoveries of the six fungicides at three added levels were 78.8 %–106.3 % (RSD 0.6 %–12.5 %). During wine-making processes, metalaxyl-M dissipated slowly (T1/2 = 248 h), while the other five fungicides dissipated rapidly (T1/2 = 17−44 h). The transfer rates of the six fungicides in wine and pomace were 0.9 %–14 % and 22 %–72 %, respectively. During the drying process, the dissipation of metalaxyl-M was very limited, and the half-lives of the other five fungicides were 39−84 h. The processing factors (PFs) of the six fungicides during wine-making and drying were 0.01-0.19 and 0.35-0.97, respectively, which indicates that these processes can reduce the residues of these six fungicides in wine and raisins. The established multianalysis method provides a reference for the simultaneous detection of target pesticides in grape and its processed products. The residue determination results provide reasonable data for reducing pesticide residues and the dietary risk factors of grapes and their processed products.

中文翻译：

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六种葡萄酿酒干燥杀菌剂的快速分析与残留评价

摘要 建立了葡萄、葡萄酒和葡萄干中甲霜灵、啶酰菌胺、嘧菌酯、氟啶虫胺及其代谢物2,6-二氯苯甲酰胺、唑菌胺酯和山莨菪酰胺的快速多分析方法。研究了6种杀菌剂在酿酒和水果干燥过程中的残留测定和评价。六种杀菌剂在所有三个基质中都表现出良好的线性 (r > 0.9953)。三种添加水平的六种杀菌剂的平均回收率为 78.8%–106.3%（RSD 0.6%–12.5%）。在酿酒过程中，甲霜灵-M消散缓慢（T1/2 = 248 h），而其他五种杀菌剂消散迅速（T1/2 = 17-44 h）。葡萄酒和果渣中六种杀菌剂的转移率分别为 0.9%–14% 和 22%–72%。在干燥过程中，甲霜灵-M的耗散非常有限，其他五种杀菌剂的半衰期为 39-84 小时。6种杀菌剂在酿酒和干燥过程中的加工因子（PFs）分别为0.01-0.19和0.35-0.97，表明这些工艺可以减少这6种杀菌剂在葡萄酒和葡萄干中的残留。建立的多元分析方法为同时检测葡萄及其加工产品中的目标农药提供了参考。残留测定结果为降低葡萄及其加工产品的农药残留和膳食危险因素提供了合理的数据。这表明这些工艺可以减少这六种杀菌剂在葡萄酒和葡萄干中的残留。建立的多元分析方法为同时检测葡萄及其加工产品中的目标农药提供了参考。残留测定结果为降低葡萄及其加工产品的农药残留和膳食危险因素提供了合理的数据。这表明这些工艺可以减少这六种杀菌剂在葡萄酒和葡萄干中的残留。建立的多元分析方法为同时检测葡萄及其加工产品中的目标农药提供了参考。残留测定结果为降低葡萄及其加工产品的农药残留和膳食危险因素提供了合理的数据。