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Pediatric-friendly chocolate-based dosage forms for the oral administration of both hydrophilic and lipophilic drugs fabricated with extrusion-based 3D printing.
European Journal of Pharmaceutical Sciences ( IF 4.3 ) Pub Date : 2020-03-02 , DOI: 10.1016/j.ejps.2020.105291 Christina Karavasili 1 , Angelos Gkaragkounis 1 , Thomas Moschakis 2 , Christos Ritzoulis 3 , Dimitrios G Fatouros 1
European Journal of Pharmaceutical Sciences ( IF 4.3 ) Pub Date : 2020-03-02 , DOI: 10.1016/j.ejps.2020.105291 Christina Karavasili 1 , Angelos Gkaragkounis 1 , Thomas Moschakis 2 , Christos Ritzoulis 3 , Dimitrios G Fatouros 1
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The aim of the current study was the development of pediatric-friendly 3D printed chocolate-based oral dosage forms. Corn syrup was used to both facilitate the incorporation of a lipophilic, namely ibuprofen or a hydrophilic, namely paracetamol, active compound that were used as model drugs and to enable 3D printing of the chocolate-based dosage forms. Physicochemical (differential scanning calorimetry, X-Ray diffraction, Fourier-Transform infrared spectroscopy, particle size distribution) and rheological studies were applied for the characterization of the prepared chocolate-based formulations. Texture profile analysis and in vitro digestion studies were performed in order to further analyze the texture attributes and to evaluate drug dissolution of the final dosage forms, respectively. In the present study, we reported on a facile method for the preparation of a 3D printed chewable chocolate-based dosage form with rapid and high release of both hydrophobic and hydrophilic drugs in simulated salivary fluid. The application of 3D printing technology enables accuracy in dose adjustment, while at the same time introducing the potential of patient's active involvement in customization of the design, textural and organoleptic properties of the final dosage form.
中文翻译：
儿科友好的基于巧克力的剂型，用于通过挤压型3D打印制成的亲水性和亲脂性药物的口服给药。
当前研究的目的是开发基于儿童的3D打印巧克力基口服剂型。玉米糖浆用于促进掺入用作模型药物的亲脂性（即布洛芬）或亲水性（即对乙酰氨基酚）活性化合物的掺入，并能够3D打印基于巧克力的剂型。物理化学（差示扫描量热法，X射线衍射，傅立叶变换红外光谱法，粒度分布）和流变学研究用于表征制备的巧克力基配方。进行了质构特征分析和体外消化研究，以分别进一步分析质构属性和评估最终剂型的药物溶出度。在目前的研究中，我们报道了一种简便的方法来制备3D打印的可咀嚼的巧克力基剂型，该方法可在模拟唾液中快速且高度释放疏水性和亲水性药物。3D打印技术的应用实现了剂量调整的准确性，同时引入了患者积极参与最终剂型的设计，质地和感官特性定制的潜力。
更新日期：2020-03-03
中文翻译：
儿科友好的基于巧克力的剂型，用于通过挤压型3D打印制成的亲水性和亲脂性药物的口服给药。
当前研究的目的是开发基于儿童的3D打印巧克力基口服剂型。玉米糖浆用于促进掺入用作模型药物的亲脂性（即布洛芬）或亲水性（即对乙酰氨基酚）活性化合物的掺入，并能够3D打印基于巧克力的剂型。物理化学（差示扫描量热法，X射线衍射，傅立叶变换红外光谱法，粒度分布）和流变学研究用于表征制备的巧克力基配方。进行了质构特征分析和体外消化研究，以分别进一步分析质构属性和评估最终剂型的药物溶出度。在目前的研究中，我们报道了一种简便的方法来制备3D打印的可咀嚼的巧克力基剂型，该方法可在模拟唾液中快速且高度释放疏水性和亲水性药物。3D打印技术的应用实现了剂量调整的准确性，同时引入了患者积极参与最终剂型的设计，质地和感官特性定制的潜力。
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