Perfluorooctane sulfonate (PFOS) is an increasingly important environmental pollutant, which has been detected almost everywhere in the environment. Despite the widespread presence of PFOS, much less notice is taken of its toxicology effects on marine bivalves. Thus, the transcriptome response to PFOS treatment (nominal concentration of 20 mg/L) in hepatopancreas of a sentinel organism, Ruditapes philippinarum was examined. Compared with the control group, 32,149 unigenes were up-regulated and 26,958 unigenes down-regulated. Notably, significant gene expression changes were found in carbohydrate metabolism, energy metabolism, amino acid metabolism, lipid metabolism and protein biosynthesis, indicating the metabolic disruptions caused by PFOS in R. philippinarum. Additionally, numerous other differentially expressed genes were involved in immune system, antioxidant defense system and detoxification metabolism. In summary, transcriptome profiling of R. philippinarum after exposure to PFOS provided molecular support for our current understanding of the detrimental toxicity of PFOS on marine bivalves.

全氟辛烷磺酸盐（PFOS）是一种日益重要的环境污染物，几乎在环境中的任何地方都可以检测到。尽管全氟辛烷磺酸广泛存在，但人们对其全氟辛烷磺酸的毒理学影响却很少注意到。因此，检查了在前哨生物菲律宾蛤仔的肝胰脏中对PFOS处理（标称浓度为20 mg / L）的转录组反应。与对照组相比，上调32,149个单基因，下调26,958个单基因。值得注意的是，在碳水化合物代谢，能量代谢，氨基酸代谢，脂质代谢和蛋白质的生物合成被发现显著基因表达的改变，这表明在所造成的全氟辛烷磺酸的代谢中断ř。菲律宾。另外，许多其他差异表达的基因也参与了免疫系统，抗氧化防御系统和排毒代谢。总之，R的转录组分析。接触全氟辛烷磺酸后的菲律宾为我们目前对全氟辛烷磺酸对海洋双壳类鱼类有害毒性的理解提供了分子支持。