Abstract Furfural is one of main inhibitors in hemicellulose hydrolysates such as xylose mother liquor, but its positive effect on the production of validamycin-A (VAL-A), a widely used agricultural antibiotic, was interestingly found in fermentation of Streptomyces hygroscopicus 5008. The furfural level in medium up to 1 g/L was effectively converted to furfuryl alcohol and furoic acid by the microorganism. Both intracellular H2O2 level and ValG enzyme activity of the cells were enhanced by furfural addition. Xylose mother liquor medium with supplementation of about 1 g/L furfural could enhance the VAL-A titer by 39 %. This work is helpful to VAL-A fermentation using the hemicellulose hydrolysate.

中文翻译：

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添加糠醛对吸湿链霉菌5008发酵产有效霉素A的影响

摘要 糠醛是木糖母液等半纤维素水解物中的主要抑制剂之一，但在吸水链霉菌 5008 的发酵中发现了它对广泛使用的农用抗生素有效霉素 A (VAL-A) 的生产有积极作用。培养基中高达 1 g/L 的糠醛水平被微生物有效地转化为糠醇和糠酸。加入糠醛后，细胞内的 H2O2 水平和细胞的 ValG 酶活性均得到增强。添加约 1 g/L 糠醛的木糖母液培养基可使 VAL-A 效价提高 39%。这项工作有助于使用半纤维素水解物进行 VAL-A 发酵。