In this issue of Structure, Cai et al. (2020) describe crystal structures of the postsynaptic protein Shank3, a homolog of cortactin binding protein 1 (CBP1), in complex with small G proteins Rap1 and H-Ras. Functional studies suggest that binding of Ras and Rap to Shank3 is modulated by synaptic plasticity.

中文翻译：

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CBP / Shank3如何保护说唱和H-Ras。

在本期《结构》中，蔡等人。（2020年）描述了突触后蛋白Shank3的晶体结构，该蛋白是cortactin结合蛋白1（CBP1）的同系物，与小G蛋白Rap1和H-Ras形成复合体。功能研究表明，Ras和Rap与Shank3的结合受到突触可塑性的调节。