Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.

中文翻译：

---

揭示了对B类GPCR选择性和激活的结构理解。

Ma等。（2020）和梁等。（2020）描述了三类BG蛋白偶联受体（GPCR）与天然肽和Gs结合的低温EM结构。他们的工作为B类GPCR建立了肽特异性的结构基础以及受体激活和G蛋白偶联的保守机制。