ABSTRACT Fluorescent molecular tomography (FMT) is emerging as a reliable optics-based molecular imaging technique. The diffusion approximation is commonly employed as a forward model for reconstruction. However, the diffusion equation is not valid in regions where the medium is low scattering or nonscattering. In addition, reconstruction based on the coarse grid will result in the low reconstruction accuracy although the computational requirements can be reduced. This paper is concerned with a new method of image reconstruction for FMT. In this method, the tomographic image of FMT is reconstructed in combination with the modelling error. Furthermore, an iterative strategy of grouped light sources is incorporated into the reconstruction process. The results attest that the proposed algorithm can speed up the reconstruction process and improve the quality of image reconstruction.

中文翻译：

---

通过补偿建模误差进行荧光分子断层扫描重建

摘要 荧光分子断层扫描 (FMT) 正在成为一种可靠的基于光学的分子成像技术。扩散近似通常用作重建的前向模型。但是，扩散方程在介质低散射或非散射的区域中无效。此外，基于粗网格的重建虽然可以减少计算要求，但会导致重建精度较低。本文关注的是一种新的 FMT 图像重建方法。该方法结合建模误差重建FMT的断层图像。此外，将分组光源的迭代策略纳入重建过程。