Purpose

To assess the possibility of using acrylic intraocular lenses (IOLs) to ensure controlled and sustained release of moxifloxacin, an antibiotic commonly used for endophthalmitis prophylaxis after cataract surgery.

Setting

Academic, industrial, and clinical partners from Portugal, Belgium, Iceland, and the United States.

Design

Experimental study.

Methods

The physical properties of IOLs loaded with moxifloxacin by soaking were characterized. In vitro drug-release studies were performed under hydrodynamic conditions similar to those of the eye, and the activity of the released drug was tested. In vitro cytotoxicity was evaluated, and the in vivo efficacy of the devices was assessed through rabbit experiments in which the effects of topical moxifloxacin drops (control) and moxifloxacin-loaded IOLs were compared.

Results

The presence of moxifloxacin in the IOLs had little effect on the evaluated physical properties and did not induce cytotoxicity. In vitro drug release experiments showed that the IOLs provided controlled release of moxifloxacin for approximately 2 weeks. The drug remained active against the tested microorganisms during that period. Moxifloxacin-loaded IOLs and the control treatment induced similar in vivo behavior in terms of inflammatory reactions, capsular bag opacification scores, and uveal and capsule biocompatibility. The drug concentration in the aqueous humor after 1 week was similar in both groups; however, the concentration with the loaded IOLs was less variable.

Conclusion

The moxifloxacin-loaded IOLs released the drug in a controlled manner, providing therapeutic levels.

中文翻译：

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装载莫西沙星的丙烯酸人工晶状体：体外和体内性能

目的

为了评估使用丙烯酸人工晶状体（IOL）来确保可控和持续释放莫西沙星的可能性，莫西沙星是白内障手术后通常用于预防眼内炎的抗生素。

设置

来自葡萄牙，比利时，冰岛和美国的学术，工业和临床合作伙伴。

设计

实验研究。

方法

表征了通过浸泡负载莫西沙星的IOL的物理特性。在类似于眼睛的流体动力学条件下进行了体外药物释放研究，并测试了释放药物的活性。评估了体外细胞毒性，并通过兔实验评估了该装置的体内功效，该实验比较了局部莫西沙星滴眼液（对照）和载有莫西沙星的IOL的作用。

结果

IOLs中莫西沙星的存在对所评估的物理性质影响很小，并且不会诱导细胞毒性。体外药物释放实验表明，IOL在约2周内提供了莫西沙星的控制释放。在此期间，该药物对被测微生物保持活性。装载莫西沙星的IOL和对照治疗在炎症反应，囊袋混浊分数，葡萄膜和胶囊的生物相容性方面诱导了相似的体内行为。两组在1周后房水中的药物浓度相似。但是，加载的IOL的浓度变化较小。

结论

装载莫西沙星的IOL以受控方式释放药物，从而提供治疗水平。