BACKGROUND Concerns have been raised that extensive use of personal care products that contain endocrine disrupting compounds increase the risk of hormone sensitive cancers. OBJECTIVE To assess the effect of skincare product use on the risk of pre- and postmenopausal breast cancer, estrogen receptor positive (ER+) and negative (ER-) breast cancer and cancer of the endometrium. METHODS We used data from 106,978 participants in the population-based Norwegian Women and Cancer cohort. Participants were categorized into non-, light, moderate, frequent and heavy users of skincare products based on self-reported use of hand and facial cream and body lotion. Cancer incidence information from the Cancer Registry of Norway was linked to individual data through the unique identity number of Norwegian citizens. Multivariable Cox proportional hazard regression was used to assess the effect of skincare product use on the risk of cancer of the breast and endometrium. We used multiple imputation by chained equations to evaluate the effect of missing data on observed associations. RESULTS We found no associations between use of skincare products and incidence of premenopausal breast cancer (frequent/heavy versus non-/light use: hazard ratio [HR] =1.10, 95% confidence interval [CI]: 0.92-1.32), postmenopausal breast cancer (heavy versus light use: HR = 0.87, 95% CI: 0.65-1.18, frequent versus light use: HR = 0.97, 95% CI: 0.88, 1.07) or endometrial cancer (frequent/heavy versus non-/light use: HR = 0.97, 95% CI: 0.79-1.20). Use of skincare products did not increase the risk of ER+ or ER- breast cancer and there was no difference in effect across ER status (0.58 ≤ pheterogeneity ≤ 0.99). The magnitude and direction of the effect estimates based on complete case analyses and multiple imputation were similar. CONCLUSION Heavy use of skincare products, i.e. creaming the body up to two times per day during mid-life, did not increase the risk of cancer of the breast or endometrium.

中文翻译：

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护肤品的使用与乳腺癌和子宫内膜癌的风险：一项前瞻性队列研究。


背景技术人们担心广泛使用含有内分泌干扰化合物的个人护理产品会增加患激素敏感性癌症的风险。目的 评估使用护肤品对绝经前和绝经后乳腺癌、雌激素受体阳性 (ER+) 和阴性 (ER-) 乳腺癌以及子宫内膜癌风险的影响。方法 我们使用了基于人群的挪威妇女和癌症队列中 106,978 名参与者的数据。根据自我报告的护手霜、面霜和身体乳液的使用情况，参与者被分为不使用、轻度、中度、频繁和重度使用护肤品。挪威癌症登记处的癌症发病率信息通过挪威公民的唯一身份号码与个人数据相关联。使用多变量 Cox 比例风险回归评估护肤品使用对乳腺癌和子宫内膜癌风险的影响。我们使用链式方程的多重插补来评估缺失数据对观察到的关联的影响。结果 我们发现使用护肤品与绝经前乳腺癌（频繁/大量使用与不使用/少量使用相比：风险比 [HR] =1.10，95% 置信区间 [CI]：0.92-1.32）、绝经后乳腺癌的发病率之间没有关联。癌症（大量使用 vs 少量使用：HR = 0.87，95% CI：0.65-1.18，频繁使用 vs 少量使用：HR = 0.97，95% CI：0.88, 1.07）或子宫内膜癌（频繁/大量使用 vs 不/少量使用： HR = 0.97，95% CI：0.79-1.20）。使用护肤品不会增加 ER+ 或 ER- 乳腺癌的风险，并且不同 ER 状态的效果没有差异 (0.58 ≤异质性 ≤ 0.99)。 基于完整案例分析和多重插补的效应估计的大小和方向是相似的。结论 大量使用护肤品，即中年期间每天最多涂抹两次护肤品，不会增加患乳腺癌或子宫内膜癌的风险。