Naphthalene is a very important skeleton in chemistry as evidenced by the large number of active compounds containing it. For this reason, methods achieving easy functionalization of naphthalene derivatives are of great importance. This review sums up reactions allowing regioselective functionalization of 1‐substituted naphthalenes based on a directed C‐H activation strategy. Indeed, over the past ten years, a lot of research groups have tried to develop new methodologies to directly introduce different functional groups on every positions of naphthalene. In addition of the possible reactions described in the literature, a special attention has been paid to mechanistic aspects in order to explain the observed regioselectivities.

中文翻译：

---

萘的区域选择性CH官能化：反应性和机理的见解。

萘是化学中非常重要的骨架，这可以通过大量含有萘的活性化合物来证明。因此，实现萘衍生物的容易的官能化的方法非常重要。这篇综述总结了基于定向C-H活化策略的1-取代萘的区域选择性功能化反应。确实，在过去的十年中，许多研究小组已尝试开发新的方法，以将不同的官能团直接引入萘的每个位置。除了文献中描述的可能的反应外，还特别关注了机械方面，以解释观察到的区域选择性。