Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes.,ChemistryOpen

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Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes.
ChemistryOpen ( IF 2.5 ) Pub Date : 2020-03-02 , DOI: 10.1002/open.201900374
Ryo Sasaki ₁ , Kohei Sato ₁ , Kazushi Kinbara ₁

Affiliation

We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH.

中文翻译：

多嵌段两亲物的芳香族氟化增强了其与脂质双层膜的结合。

我们设计了多嵌段两亲物AmF和AmH ，它们分别由全氟化和非氟化疏水单元组成。吸收光谱表明，两种两亲物都以分子形式分散在有机溶剂中，而它们在水性条件下形成聚集体。此外，我们研究了AmF和AmH是否可以掺入DOPC脂双层膜，发现AmF可以掺入DOPC脂双层膜的最大浓度是AmH的43倍。

更新日期：2020-03-02

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