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Ultrasound‐assisted efficient synthesis of polyfunctional 1,2,4‐triazoles as novel antibacterial and antioxidant agents
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2020-03-02 , DOI: 10.1002/jccs.201900430 Sahar Dastmard 1 , Manouchehr Mamaghani 1 , Mehdi Rassa 2
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2020-03-02 , DOI: 10.1002/jccs.201900430 Sahar Dastmard 1 , Manouchehr Mamaghani 1 , Mehdi Rassa 2
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Novel 4,5‐diphenyl‐1H ‐imidazol‐1‐yl‐1H ‐1,2,4‐triazole derivatives were synthesized using a facile and highly efficient, one‐pot, four‐component procedure in the presence of KHSO4 as an acidic catalyst under ultrasonic irradiations in short reaction times (10–25 min) and good to excellent yields (70–96%). The synthesized compounds were screened for their antibacterial activities against Gram‐negative (Escherichia coli , Pseudomonas aeruginosa ) and Gram‐positive (Bacillus subtilis , Micrococcus luteus ) bacteria, and their antioxidant activity was also evaluated. Some of the products showed potential antibacterial and high antioxidant activities.
中文翻译：
超声辅助高效合成多官能1,2,4-三唑类化合物作为新型抗菌和抗氧化剂
在KHSO 4存在下，采用简便高效的单锅四组分方法合成了新颖的4,5-二苯基-1 H-咪唑-1-基-1 H -1,2,4-三唑衍生物在短时间内（10–25分钟）超声辐照下作为酸性催化剂，并具有良好至极好的收率（70–96％）。筛选合成的化合物对革兰氏阴性菌（大肠杆菌，铜绿假单胞菌）和革兰氏阳性菌（枯草芽孢杆菌，琵琶微球菌）的抗菌活性，并评估其抗氧化活性。一些产品显示出潜在的抗菌和高抗氧化活性。
更新日期：2020-03-02
中文翻译：
超声辅助高效合成多官能1,2,4-三唑类化合物作为新型抗菌和抗氧化剂
在KHSO 4存在下，采用简便高效的单锅四组分方法合成了新颖的4,5-二苯基-1 H-咪唑-1-基-1 H -1,2,4-三唑衍生物在短时间内（10–25分钟）超声辐照下作为酸性催化剂，并具有良好至极好的收率（70–96％）。筛选合成的化合物对革兰氏阴性菌（大肠杆菌，铜绿假单胞菌）和革兰氏阳性菌（枯草芽孢杆菌，琵琶微球菌）的抗菌活性，并评估其抗氧化活性。一些产品显示出潜在的抗菌和高抗氧化活性。
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