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Silver-Laden Black Phosphorus Nanosheets for an Efficient In Vivo Antimicrobial Application.
Small ( IF 13.0 ) Pub Date : 2020-03-01 , DOI: 10.1002/smll.201905938
Meijuan Liang 1 , Minyi Zhang 2 , Shanshan Yu 1 , Qiong Wu 1 , Kang Ma 1 , Yingying Chen 1 , Xiaoqing Liu 1 , Chunsen Li 2 , Fuan Wang 1
Affiliation  

Nanobactericides represent one of the most efficient and promising strategies for eliminating bacterial infection considering the increasing resistance threats of conventional antibiotics. Black phosphorus (BP) is the most exciting postgraphene layered 2D nanomaterial with convincing physiochemical properties, yet the study of BP-based antibiotics is still in its infancy. Here, a compact silver nanoparticle (AgNP)-doped black phosphorus nanosheet (BPN) is constructed to synergistically enhance solar disinfection through the promoted reactive oxygen species (ROS) photogeneration, which is attributed to the improved electron-hole separation and recombination of BPNs as revealed from the systematic experimental studies. An in-depth density functional theory (DFT) calculation confirms that the integrated AgNPs provide a preferred site for facilitating the adsorption and activation of O2 , thus promoting the more efficient and robust ROS generation on BPN-AgNP nanohybrids. Besides the enhanced photoinduced ROS, the anchored AgNPs simultaneously lead to a dramatically increased affinity toward bacteria, which facilitates a synergetic pathogen inactivation. Significantly, the convincing antimicrobial BPN-AgNP contributes to the prominent wound healing and antimicrobial ability in vivo with minimized biological burden. This sophisticated design of new 2D nanohybrids opens a new avenue for further exploiting BP-based nanohybrids in portable bandage and broad-spectrum disinfection applications.

中文翻译:

高效的体内抗菌应用的载银黑磷纳米片。

考虑到常规抗生素的耐药性威胁不断增加,纳米杀菌剂是消除细菌感染的最有效,最有前途的策略之一。黑磷(BP)是最令人兴奋的具有令人信服的理化性质的石墨烯层二维二维纳米材料,但是基于BP的抗生素的研究仍处于起步阶段。在这里,构造了紧凑的银纳米颗粒(AgNP)掺杂的黑磷纳米片(BPN),以通过促进活性氧(ROS)的光生作用来协同增强太阳能消毒,这归因于BPNs的电子-空穴分离和重组的改善。从系统的实验研究中发现。深入的密度泛函理论(DFT)计算证实,集成的AgNPs为促进O2的吸附和活化提供了一个优选的位点,从而促进了BPN-AgNP纳米杂化物上更有效,更强大的ROS生成。除了增强的光诱导活性氧(ROS)之外,锚定的AgNPs同时导致与细菌的亲和力急剧增加,从而促进了病原体的协同失活。重要的是,令人信服的抗菌剂BPN-AgNP有助于体内显着的伤口愈合和抗菌能力,同时使生物学负担降至最低。新型2D纳米杂化物的复杂设计为在便携式绷带和广谱消毒应用中进一步开发基于BP的纳米杂化物开辟了一条新途径。因此促进了BPN-AgNP纳米杂化物的更有效和更强的ROS生成。除了增强的光诱导活性氧(ROS)外,锚定的AgNP还同时导致与细菌的亲和力急剧增加,从而促进了病原体的协同灭活。重要的是,令人信服的抗菌剂BPN-AgNP有助于体内显着的伤口愈合和抗菌能力,同时使生物学负担降至最低。新型2D纳米杂化物的复杂设计为在便携式绷带和广谱消毒应用中进一步开发基于BP的纳米杂化物开辟了一条新途径。因此促进了BPN-AgNP纳米杂化物的更有效和更强的ROS生成。除了增强的光诱导活性氧(ROS)之外,锚定的AgNPs同时导致与细菌的亲和力急剧增加,从而促进了病原体的协同失活。重要的是,令人信服的抗菌剂BPN-AgNP有助于体内显着的伤口愈合和抗菌能力,同时使生物学负担降至最低。新型2D纳米杂化物的复杂设计为在便携式绷带和广谱消毒应用中进一步开发基于BP的纳米杂化物开辟了一条新途径。令人信服的抗菌剂BPN-AgNP有助于在体内显着降低伤口的愈合和抗菌能力。新型2D纳米杂化物的复杂设计为在便携式绷带和广谱消毒应用中进一步开发基于BP的纳米杂化物开辟了一条新途径。令人信服的抗菌剂BPN-AgNP有助于体内显着的伤口愈合和抗菌能力,同时使生物学负担降至最低。新型2D纳米杂化物的复杂设计为在便携式绷带和广谱消毒应用中进一步开发基于BP的纳米杂化物开辟了一条新途径。
更新日期:2020-04-03
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