Gold nanoparticle-conjugated nanomedicine: design, construction, and structure-efficacy relationship studies.,Journal of Materials Chemistry B

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Gold nanoparticle-conjugated nanomedicine: design, construction, and structure-efficacy relationship studies.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-03-02 , DOI: 10.1039/c9tb02924a
Wenjie Wang ₁ , Jing Wang ₁ , Ya Ding ₁

Affiliation

In comparison with conventional therapies, nanomedicine shows prominent clinical performance, with better therapeutic efficacy and less off-target toxicity. As an important component of nanomedicine, gold nanoparticle (GNP)-based nanodrugs have attracted considerable interest because of their excellent performance given by the unique structure. Although no pharmaceutical formulations of GNP-associated nanodrugs have been officially marketed yet, a substantial amount of research on this aspect is being carried out, producing numerous GNP-based drug delivery systems with potential clinical applications. In this review, we present an overview of our progress on GNP-based nanodrugs combined with other achievements in biomedical applications, including drug-conjugated GNPs prepared for disease treatments and specific tumour targeting, structure–efficacy relationship (SER) studies on GNP-conjugated nanodrugs, and therapeutic hybrid nanosystems composed of GNPs. In addition, we also put forward some proposals to guide future work in developing GNP-based nanomedicine. We hope that this review will offer some useful experience for our peers and GNP-based nanodrugs will be utilized in the clinic with further persistent efforts.

中文翻译：

金纳米粒子共轭纳米药物：设计，构造和结构功效关系研究。

与传统疗法相比，纳米药物表现出突出的临床表现，具有更好的疗效和更少的脱靶毒性。作为纳米药物的重要组成部分，基于金纳米颗粒（GNP）的纳米药物由于其独特的结构具有出色的性能而备受关注。尽管尚未正式销售与GNP相关的纳米药物的药物制剂，但有关这一方面的大量研究正在进行，产生了许多具有潜在临床应用的基于GNP的药物递送系统。在这篇评论中，我们概述了基于GNP的纳米药物的研究进展以及在生物医学应用中的其他成就，包括为疾病治疗和特定肿瘤靶向而制备的药物偶联GNP，GNP共轭纳米药物的结构-功效关系（SER）研究，以及由GNP组成的治疗性混合纳米系统。此外，我们还提出了一些建议，以指导未来开发基于GNP的纳米药物。我们希望这项审查将为我们的同行提供一些有益的经验，并且在进一步的不懈努力下，基于GNP的纳米药物将用于临床。

更新日期：2020-03-02

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