Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties,Soft Matter

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Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties
Soft Matter ( IF 2.9 ) Pub Date : 2020/03/02 , DOI: 10.1039/c9sm02075f
Wiktor Kasprzyk _{1,

2,

3,

4,

5} , Szczepan Bednarz _{1,

2,

3,

4,

5} , Dariusz Bogdał _{1,

2,

3,

4,

5} , Guillermo A. Ameer _{6,

7,

8,

9} , Tomasz Świergosz _{2,

3,

4,

5,

10}

Affiliation

Herein, we describe the synthesis of poly(1,8-octamethylene citrate) materials modified in the bulk with 2-hydroxypropyl-β-cyclodextrin (cPOCCD), biodegradable elastomers with intrinsic sorption properties for drug delivery. The chemical structure, physicochemical properties, in vitro drug loading and release profiles of cPOCCD were investigated. Thus, cPOCCD polyesters absorb the studied drugs more effective and release them for a longer period of time than poly(1,8-octamethylene citrate) materials not containing cyclodextrins.

中文翻译：

环糊精改性的聚柠檬酸八亚甲基酯聚合物，可提高吸附性能

在这里，我们描述了用2-羟丙基-β-环糊精（cPOCCD），具有生物吸附性的可生物降解的弹性体，在药物输送中进行了整体改性的聚（1,8-辛酸亚甲基柠檬酸酯）材料的合成。研究了cPOCCD的化学结构，理化性质，体外载药量和释放曲线。因此，与不含环糊精的聚（1,8-辛二酸柠檬酸）酯材料相比，cPOCCD聚酯可更有效地吸收所研究的药物并释放更长的时间。

更新日期：2020-04-01

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