NMR-based metabolomics and fluxomics: developments and future prospects,Analyst

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NMR-based metabolomics and fluxomics: developments and future prospects
Analyst ( IF 3.6 ) Pub Date : 2020/03/02 , DOI: 10.1039/d0an00142b
Patrick Giraudeau _{1,

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Affiliation

NMR spectroscopy is an essential analytical technique in metabolomics and fluxomics workflows, owing to its high structural elucidation capabilities combined with its intrinsic quantitative nature. However, routine NMR “omic” analytical methods suffer from several drawbacks that may have limited their use as a method of choice, in particular when compared to another widely used technique, mass spectrometry. This review describes, in a critical and perspective discussion, how some of the most recent developments emerging from the NMR community could act as real game changers for metabolomics and fluxomics in the near future. Advanced developments to make NMR metabolomics more resolutive, more sensitive and more accessible are described, as well as new approaches to improve the identification of biomarkers. We hope that this review will convince a broad end-user community of the increasing role of NMR in the “omic” world at the beginning of the 2020s.

中文翻译：

基于核磁共振的代谢组学和通量组学：发展和未来前景

NMR光谱法是代谢组学和通量组学工作流程中必不可少的分析技术，这是由于其具有很高的结构解析能力以及其固有的定量性质。但是，常规NMR“组学”分析方法存在一些缺点，这些缺点可能限制了它们作为一种选择方法的使用，特别是与另一种广泛使用的技术质谱法相比时。这篇评论通过批判性和前瞻性的讨论，描述了NMR社区最新出现的一些最新发展如何在不久的将来成为代谢组学和通量组学的真正改变者。描述了使NMR代谢组学更具有分辨力，灵敏度和可访问性的先进技术，以及改进生物标记物鉴定的新方法。

更新日期：2020-03-31

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