Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1,642 contacts of 94 Nipah case-patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case-patients who died, peaked on the day of death. Given transmission has only been observed among fatal Nipah cases, our findings suggest changes in contact patterns during illness contribute to risk of infection.

中文翻译：

---

在疾病进展过程中改变接触方式：以尼帕病毒为例。

接触方式在疾病传播中起关键作用，在疾病过程中接触的变化会影响传播，尤其是伴随宿主传染性的变化。我们对孟加拉国94名Nipah病例患者的1,642位接触者进行了调查，以确定随着疾病严重程度的发展，接触方式（体液和体液）如何变化。接触的数量随着严重程度的增加而增加，并且对于死亡的病例患者，在死亡当天达到峰值。由于仅在致命的尼帕病病例中观察到传播，我们的发现表明，疾病期间接触方式的变化会增加感染的风险。