A handheld low temperature plasma (LTP) device has been developed for safe and effective wound healing. The room temperature, long operating range plasma produced by this device was acceptable for the genetic diabetic db/db mice. Three working gas admixture ratios, helium only, helium +0.1% O 2 and helium +1% O 2 , of the LTP device were compared on the wound healing efficiency. The LTP with the working gas of helium +0.1% O 2 , produced more RONS. Its higher concentration of ROS resulted in higher sterilization efficiency, which decreased the oxygen consumed by bacteria and increased the oxygen supply to extracellular matrix and growing blood vessels. Its higher concentration of NO stimulated keratinocytes to secret growth factors. Therefore, it realized faster chronic wound healing. The other working gases admixture ratio were also effective in the wound healing promotion in diabetic mice. Taken together, these results suggest that LTP can be used t...

中文翻译：

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低温血浆促进糖尿病小鼠慢性伤口的愈合

已经开发了一种手持式低温等离子体（LTP）设备，用于安全有效的伤口愈合。由该装置产生的室温，长工作范围血浆对于遗传性糖尿病db / db小鼠是可接受的。比较了LTP设备的三种工作气体混合比（仅氦气，氦气+ 0.1％O 2和氦气+ 1％O 2）的伤口愈合效率。具有氦气+ 0.1％O 2的LTP产生更多的RONS。较高的ROS浓度导致较高的灭菌效率，从而减少了细菌消耗的氧气，并增加了向细胞外基质和生长中的血管的氧气供应。其较高浓度的NO刺激角质​​形成细胞分泌秘密的生长因子。因此，它实现了更快的慢性伤口愈合。其他工作气体的混合比例在糖尿病小鼠的伤口愈合促进中也有效。综上所述，这些结果表明LTP可以用于...