A pair of geometrically isomeric unsaturated keto fatty acids, (6E,8Z)- and (6E,8E)-5-oxo-6,8-tetradecadienoic acids (1 and 2), were isolated from the culture broth of an actinomycete of the genus Micrococcus, which was associated with a stony coral, Catalaphyllia sp. Their chemical structures were elucidated by spectroscopic analysis including NMR and MS, with special assistance of spin system simulation studies for the assignment of an E geometry at C8 in 2. As metabolites of microbes, compounds 1 and 2 are unprecedented in terms of bearing a 2,4-dienone system. Both 1 and 2 showed antibacterial activity against the plant pathogen Rhizobium radiobacter and the fish pathogen Tenacibaculum maritimum, with a contrasting preference that 1 is more effective to the former strain while 2 is so to the latter. In addition, compounds 1 and 2 displayed agonistic activity against peroxisome proliferator-activated receptors (PPARs) with an isoform specificity towards PPARα and PPARγ.

中文翻译：

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来自微球菌属的珊瑚相关放线菌的两种抗菌和PPARα/γ激动性不饱和酮脂肪酸

从的培养液中分离了一对几何异构的不饱和酮脂肪酸（6 E，8 Z）和（6 E，8 E）-5-氧代-6,8-十四碳二烯酸（1和2）。Micrococcus属的放线菌，与石质珊瑚Catalaphyllia sp。相关。通过包括NMR和MS在内的光谱分析阐明了它们的化学结构，并特别借助自旋系统模拟研究对C8 in 2中的E几何进行了赋值。作为微生物的代谢产物，化合物1和2在承载2，4-二烯酮体系方面是前所未有的。既1和2显示出对植物病原体的抗菌活性根瘤菌放射形和鱼病原体黏着maritimum，具有形成对比的首选项1更有效的是前者应变而2是这样后者。此外，化合物1和2对过氧化物酶体增殖物激活的受体（PPAR）表现出激动活性，并且对PPARα和PPARγ具有同种型特异性。