Dietary intake and obesity can alter the composition of the gut microbiota thereby affecting the health of the host. It is unclear if intake of glucosinolate-containing cruciferous vegetables alters the composition of the gut microbiota in obesity. The aim of this study was to compare the gut microbiota composition between six diet-induced obese rats receiving Wasabia japonica (wasabi) supplementation (5% (w/w)) for eight weeks and six control diet-induced obese rats by 16S rRNA amplicon sequencing. Supplementation with wasabi reduced beta but not alpha diversity in obese rats and was associated with increased abundance of the bacterial genera Allobaculum, Bifidobacterium and Unclassified S24-7 and decreased abundance of Unclassified Enterobacteriaceae, Unclassified Ruminococcaceae, Unclassified Lachnospiraceae and Unclassified Desulfovibrionaceae. Supplementation with wasabi is predicted to result in less bacterial biosynthesis of fatty acids and phospholipids, which may lead to improved host lipid markers in diet-induced obese rats.

饮食摄入和肥胖会改变肠道菌群的组成，从而影响宿主的健康。目前尚不清楚摄入含芥子油苷的十字花科蔬菜是否会改变肥胖中肠道菌群的组成。这项研究的目的是比较16S rRNA扩增子与六只饮食诱导的肥胖大鼠在8周内接受Wasabia japonica（芥末）（5％（w / w））的肠道菌群组成与六只对照饮食诱导的肥胖大鼠之间的肠道菌群组成。排序。芥末的添加降低了肥胖大鼠的β多样性，但没有降低α多样性，并且与细菌类同种异位菌，双歧杆菌和未分类S24-7的丰度增加以及S24-7的丰度降低有关。未分类的肠杆菌科细菌，未分类Ruminococcaceae，未分类的毛螺和未分类Desulfovibrionaceae。预计补充芥末会减少脂肪酸和磷脂的细菌生物合成，这可能会导致饮食诱发的肥胖大鼠的宿主脂质标记物得到改善。